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Número de registros en este nivel: 91.

2026

With the growing academic pressure and competitive educational environment, students often face mental stress, which can affect their academic performance and mental health. Its accurate and timely detection and prevention is important. Traditionally, mental stress has been reported by self-assessment, which is highly subjective and can be erroneous. With advances in neuroscience, electroencephalogram (EEG) signals have been used to study brain states more objectively. EEG-based features, including time-domain, frequency-domain, and various types of connectivity features, have been used to effectively classify stress signals. However, these individual features are only able to present one aspect of the brain under stress. Several studies have combined a distinct set of features extracted from EEG signals, including time and frequency domain features, with other peripheral signals. Stress is a complex mechanism which leads to alternation in brain dynamics, its connectivity patterns and information flow. This study proposed a feature-fusion model that can effectively combine spatial features, i.e. Microstates (MS), connectivity features like Transfer Entropy (TE) and Granger Causality (GC), which provided a new neuromarker for stress classification. These features are combined with attention fusion, which enhances the discriminant features and mitigates the individual limitations within each modality. We also extracted microstates for stress-based signals. It provided a new set of microstate topomaps to study brain networks when under stress, which was not explored previously. The proposed Attention-fusion based multi-feature set is classified using Support Vector Machine, Linear Discriminant Analysis (LDA) and Multilayer Perceptron (MLP) and gave a reliable accuracy of 95.47%, 98.91%, and 83.49%, respectively. To validate the proposed method, the classification results were compared with individual and binary fusion of MS, TE and GC features, which further confirmed the robustness of the framework. This proposed feature fusion provides a more robust stress classification neuromarker, which can effectively cover the brain dynamics for accurate reporting of the underlying mental state.

Attention-based multi-feature fusion neuromarker for EEG-driven stress classification in learners.

Histopathological evaluation is necessary for the diagnosis and grading of prostate cancer, which is still one of the most common cancers in men globally. Traditional evaluation is time-consuming, prone to inter-observer variability, and challenging to scale. The clinical usefulness of current AI systems is limited by the need for comprehensive pixel-level annotations. The objective of this research is to develop and evaluate a large-scale benchmarking study on a weakly supervised deep learning framework that minimizes the need for annotation and ensures interpretability for automated prostate cancer diagnosis and International Society of Urological Pathology (ISUP) grading using whole slide images (WSIs). This study rigorously tested six cutting-edge multiple instance learning (MIL) architectures (CLAM-MB, CLAM-SB, ILRA-MIL, AC-MIL, AMD-MIL, WiKG-MIL), three feature encoders (ResNet50, CTransPath, UNI2), and four patch extraction techniques (varying sizes and overlap) using the PANDA dataset (10,616 WSIs), yielding 72 experimental configurations. The methodology used distributed cloud computing to process over 31 million tissue patches, implementing advanced attention mechanisms to ensure clinical interpretability through Grad-CAM visualizations. The optimum configuration (UNI2 encoder with ILRA-MIL, 256 256 patches, 50% overlap) achieved 78.75% accuracy and 90.12% quadratic weighted kappa (QWK), outperforming traditional methods and approaching expert pathologist-level diagnostic capability. Overlapping smaller patches offered the best balance of spatial resolution and contextual information, while domain-specific foundation models performed noticeably better than generic encoders. This work is the first large-scale, comprehensive comparison of weekly supervised MIL methods for prostate cancer diagnosis and grading. The proposed approach has excellent clinical diagnostic performance, scalability, practical feasibility through cloud computing, and interpretability using visualization tools.

Benchmarking multiple instance learning architectures from patches to pathology for prostate cancer detection and grading using attention-based weak supervision.

Introduction: Jackfruit cultivation is highly affected by leaf diseases that reduce yield, fruit quality, and farmer income. Early diagnosis remains challenging due to the limitations of manual inspection and the lack of automated and scalable disease detection systems. Existing deep-learning approaches often suffer from limited generalization and high computational cost, restricting real-time field deployment. Methods: This study proposes CNNAttLSTM, a hybrid deep-learning architecture integrating Convolutional Neural Networks (CNN), Long Short-Term Memory (LSTM) units, and an attention mechanism for multi-class classification of algal leaf spot, black spot, and healthy jackfruit leaves. Each image is divided into ordered 56×56 spatial patches, treated as pseudo-temporal sequences to enable the LSTM to capture contextual dependencies across different leaf regions. Spatial features are extracted via Conv2D, MaxPooling, and GlobalAveragePooling layers; temporal modeling is performed by LSTM units; and an attention mechanism assigns adaptive weights to emphasize disease-relevant regions. Experiments were conducted on a publicly available Kaggle dataset comprising 38,019 images, using predefined training, validation, and testing splits. Results: The proposed CNNAttLSTM model achieved 99% classification accuracy, outperforming the baseline CNN (86%) and CNN–LSTM (98%) models. It required only 3.7 million parameters, trained in 45 minutes on an NVIDIA Tesla T4 GPU, and achieved an inference time of 22 milliseconds per image, demonstrating high computational efficiency. The patch-based pseudo-temporal approach improved spatial–temporal feature representation, enabling the model to distinguish subtle differences between visually similar disease classes. Discussion: Results show that combining spatial feature extraction with temporal modeling and attention significantly enhances robustness and classification performance in plant disease detection. The lightweight design enables real-time and edge-device deployment, addressing a major limitation of existing deep-learning techniques. The findings highlight the potential of CNNAttLSTM for scalable, efficient, and accurate agricultural disease monitoring and broader precision agriculture applications.

CNNAttLSTM: an attention-enhanced CNN–LSTM architecture for high-precision jackfruit leaf disease classification.

Correction: Enhancing fault detection in new energy vehicles via novel ensemble approach.

Curcumina en niños con trastorno del espectro autista: inflamación sistémica, regulación sensorial y trastornos de la interacción intestino-cerebro. Ensayo clínico aleatorizado, doble ciego y controlado con placebo (CURATEA).

End-to-end emergency response protocol for tunnel accidents augmentation with reinforcement learning.

Enhancing fault detection in new energy vehicles via novel ensemble approach.

Human activity recognition (HAR) is essential in many applications, such as smart homes, assisted living, healthcare monitoring, rehabilitation, physiotherapy, and geriatric care. Conventional methods of HAR use wearable sensors, e.g., acceleration sensors and gyroscopes. However, they are limited by issues such as sensitivity to position, user inconvenience, and potential health risks with long-term use. Optical camera systems that are vision-based provide an alternative that is not intrusive; however, they are susceptible to variations in lighting, intrusions, and privacy issues. The paper uses an optical method of recognizing human domestic activities based on pose estimation and deep learning ensemble models. The skeletal keypoint features proposed in the current methodology are extracted from video data using PoseNet to generate a privacy-preserving representation that captures key motion dynamics without being sensitive to changes in appearance. A total of 30 subjects (15 male and 15 female) were sampled across 2734 activity samples, including nine daily domestic activities. There were six deep learning architectures, namely, the Transformer (Transformer), Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), Multilayer Perceptron (MLP), One-Dimensional Convolutional Neural Network (1D CNN), and a hybrid Convolutional Neural Network–Long Short-Term Memory (CNN–LSTM) architecture. The results on the hold-out test set show that the CNN–LSTM architecture achieves an accuracy of 98.78% within our experimental setting. Leave-One-Subject-Out cross-validation further confirms robust generalization across unseen individuals, with CNN–LSTM achieving a mean accuracy of 97.21% ± 1.84% across 30 subjects. The results demonstrate that vision-based pose estimation with deep learning is a useful, precise, and non-intrusive approach to HAR in smart healthcare and home automation systems.

Human Activity Recognition in Domestic Settings Based on Optical Techniques and Ensemble Models.

Inflammatory potential of the diet and self-rated quality of life in Italian adults.

Background/Objectives: The growing integration of Artificial Intelligence (AI) and chatbots in health professional education offers innovative methods to enhance learning and clinical preparedness. This study aimed to evaluate the educational impact and perceptions in university students of Human Nutrition and Dietetics, regarding the utility, usability, and design of the E+DIEting_Lab chatbot platform when implemented in clinical nutrition training. Methods: The platform was piloted from December 2023 to April 2025 involving 475 students from multiple European universities. While all 475 students completed the initial survey, 305 finished the follow-up evaluation, representing a 36% attrition rate. Participants completed surveys before and after interacting with the chatbots, assessing prior experience, knowledge, skills, and attitudes. Data were analyzed using descriptive statistics and independent samples t-tests to compare pre- and post-intervention perceptions. Results: A total of 475 university students completed the initial survey and 305 the final evaluation. Most university students were females (75.4%), with representation from six languages and diverse institutions. Students reported clear perceived learning gains: 79.7% reported updated practical skills in clinical dietetics and communication were updated, 90% felt that new digital tools improved classroom practice, and 73.9% reported enhanced interpersonal skills. Self-rated competence in using chatbots as learning tools increased significantly, with mean knowledge scores rising from 2.32 to 2.66 and skills from 2.39 to 2.79 on a 0–5 Likert scale (p < 0.001 for both). Perceived effectiveness and usefulness of chatbots as self-learning tools remained positive but showed a small decline after use (effectiveness from 3.63 to 3.42; usefulness from 3.63 to 3.45), suggesting that hands-on experience refined, but did not diminish, students’ overall favorable views of the platform. Conclusions: The implementation and pilot evaluation of the E+DIEting_Lab self-learning virtual patient chatbot platform demonstrate that structured digital simulation tools can significantly improve perceived clinical nutrition competences. These findings support chatbot adoption in dietetics curricula and inform future digital education innovations.

Innovative Application of Chatbots in Clinical Nutrition Education: The E+DIEting_Lab Experience in University Students.

An Integrated Machine Learning and Genomic Framework for Precise Detection of Gastric Cancer.

Liquorice alters adipocyte–breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin–angiotensin signalling.

Loneliness, Aloneness, and Adherence to the Mediterranean Diet in Southern Italian Individuals.

Suicide Ideation Detection Using Social Media Data and Ensemble Machine Learning Model.

A Systematic Literature Review on Integrated Deep Learning and Multi-Agent Vision-Language Frameworks for Pathology Image Analysis and Report Generation.

An attention-based deep learning model for early detection of polyphagous shot hole borer infestations in plants.

A novel approach for disease and pests detection in potato production system based on deep learning.

2025

Advancing fake news combating using machine learning: a hybrid model approach.

Association between blood cortisol levels and numerical rating scale in prehospital pain assessment.

Botnet detection in internet of things using stacked ensemble learning model.

Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies.

In the rapidly advanced and evolving information technology industry, adequate client engagement plays a critical role as it is very important to understand the client’s concerns, and requirements, have the records, authorizations, and go-ahead of previously agreed requirements, and provide the feasible solution accordingly. Previously multiple solutions have been proposed to enhance the efficiency of client engagement, but they lack traceability, trust, transparency, and conflict in agreements of previous contracts. Due to the lack of these shortcomings, the client requirement is getting delayed which is causing client escalations, integrity issues, project failure, and penalties. In this study, we proposed the UniferCollab framework to overcome the issues of collaboration between various teams, transparency, the record of client authorizations, and the go-ahead on previous developments by implementing blockchain technology. We store the data on the permissible network in the proposed approach. It allows us to compile all the requirements and information shared by clients on permissible blockchain to secure a large amount of data which enhances the traceability of all the requirements. All the authorizations from the client generate push notifications for any changes in their current system executed through smart contracts. It removes the ambiguity between various development teams if the client has only shared the requirement with one team. The data is stored in the decentralized network from where information is gathered which resolves the traceability, transparency, and trust issues. Lastly, evaluations involved a total of 800 hypertext transfer protocol (HTTP) requests tested using Postman with blockchain block sizes ranging from 0.568 KB to 550 KB and an average size increase of 280 KB was observed as new blocks were added. The longest chain in the network was observed during 800 repetitions of blockchain operations. Latency analysis revealed that delays in processing HTTP requests were influenced by decentralized node processing, local machine response times, and internet bandwidth through various experiments. Results show that the proposed framework resolves all client engagement issues in implementation between all stakeholders which enhances trust, and transparency improves client experience and helps us manage disputes effectively.

Client engagement solution for post implementation issues in software industry using blockchain.

Deep image features sensing with multilevel fusion for complex convolution neural networks & cross domain benchmarks.

Detecting hate in diversity: a survey of multilingual code-mixed image and video analysis.

Detection of cotton crops diseases using customized deep learning model.

Divulging Patterns: An Analytical Review for Machine Learning Methodologies for Breast Cancer Detection.

Mango is one of the most beloved fruits and plays an indispensable role in the agricultural economies of many tropical countries like Pakistan, India, and other Southeast Asian countries. Similar to other fruits, mango cultivation is also threatened by various diseases, including Anthracnose and Red Rust. Although farmers try to mitigate such situations on time, early and accurate detection of mango diseases remains challenging due to multiple factors, such as limited understanding of disease diversity, similarity in symptoms, and frequent misclassification. To avoid such instances, this study proposes a multimodal deep learning framework that leverages both leaf and fruit images to improve classification performance and generalization. Individual CNN-based pre-trained models, including ResNet-50, MobileNetV2, EfficientNet-B0, and ConvNeXt, were trained separately on curated datasets of mango leaf and fruit diseases. A novel Modality Attention Fusion (MAF) mechanism was introduced to dynamically weight and combine predictions from both modalities based on their discriminative strength, as some diseases are more prominent on leaves than on fruits, and vice versa. To address overfitting and improve generalization, a class-aware augmentation pipeline was integrated, which performs augmentation according to the specific characteristics of each class. The proposed attention-based fusion strategy significantly outperformed individual models and static fusion approaches, achieving a test accuracy of 99.08%, an F1 score of 99.03%, and a perfect ROC-AUC of 99.96% using EfficientNet-B0 as the base. To evaluate the model’s real-world applicability, an interactive web application was developed using the Django framework and evaluated through out-of-distribution (OOD) testing on diverse mango samples collected from public sources. These findings underline the importance of combining visual cues from multiple organs of plants and adapting model attention to contextual features for real-world agricultural diagnostics.

Dual-modality fusion for mango disease classification using dynamic attention based ensemble of leaf & fruit images.

Edge-Based Autonomous Fire and Smoke Detection Using MobileNetV2.

Efficient CNN architecture with image sensing and algorithmic channeling for dataset harmonization.

Enhanced FPGA-based smart power grid simulation using Heun and Piecewise analytic method.

Enhancing detection of epileptic seizures using transfer learning and EEG brain activity signals.

Ensemble stacked model for enhanced identification of sentiments from IMDB reviews.

Fundus image classification using feature concatenation for early diagnosis of retinal disease.

Harnessing AI forward and backward chaining with telemetry data for enhanced diagnostics and prognostics of smart devices.

Background/Objectives: Estimating energy and macronutrients from food images is clinically relevant yet challenging, and rigorous evaluation requires transparent accuracy metrics with uncertainty and clear acknowledgement of reference data limitations across heterogeneous sources. This study assessed ChatGPT-5, a general-purpose vision-language model, across four scenarios differing in the amount and type of contextual information provided, using a composite dataset to quantify accuracy for calories and macronutrients. Methods: A total of 195 dishes were evaluated, sourced from Allrecipes.com, the SNAPMe dataset, and Home-prepared, weighed meals. Each dish was evaluated under Case 1 (image only), Case 2 (image plus standardized non-visual descriptors), Case 3 (image plus ingredient lists with amounts), and Case 4 (replicates Case 3 but excluding the image). The primary endpoint was kcal Mean Absolute Error (MAE); secondary endpoints included Median Absolute Error (MedAE) and Root Mean Square Error (RMSE) for kcal and macronutrients (protein, carbohydrates, and lipids), all reported with 95% Confidence Intervals (CIs) via dish-level bootstrap resampling and accompanied by absolute differences (Δ) between scenarios. Inference settings were standardized to support reproducibility and variance estimation. Source stratified analyses and quartile summaries were conducted to examine heterogeneity by curation level and nutrient ranges, with additional robustness checks for error complexity relationships. Results and Discussion: Accuracy improved from Case 1 to Case 2 and further in Case 3 for energy and all macronutrients when summarized by MAE, MedAE, and RMSE with 95% CIs, with absolute reductions (Δ) indicating material gains as contextual information increased. In contrast to Case 3, estimation accuracy declined in Case 4, underscoring the contribution of visual cues. Gains were largest in the Home-prepared dietitian-weighed subset and smaller yet consistent for Allrecipes.com and SNAPMe, reflecting differences in reference curation and measurement fidelity across sources. Scenario-level trends were concordant across sources, and stratified and quartile analyses showed coherent patterns of decreasing absolute errors with the provision of structured non-visual information and detailed ingredient data. Conclusions: ChatGPT-5 can deliver practically useful calorie and macronutrient estimates from food images, particularly when augmented with standardized nonvisual descriptors and detailed ingredients, as evidenced by reductions in MAE, MedAE, and RMSE with 95% CIs across scenarios. The decline in accuracy observed when the image was omitted, despite providing detailed ingredient information, indicates that visual cues contribute meaningfully to estimation performance and that improvements are not solely attributable to arithmetic from ingredient lists. Finally, to promote generalizability, it is recommended that future studies include repeated evaluations across diverse datasets, ensure public availability of prompts and outputs, and incorporate systematic comparisons with non-artificial-intelligence baselines.

Image-Based Dietary Energy and Macronutrients Estimation with ChatGPT-5: Cross-Source Evaluation Across Escalating Context Scenarios.

Incorporating soil information with machine learning for crop recommendation to improve agricultural output.

Mediterranean Diet and Quality of Life in Adults: A Systematic Review.

Metaheuristic-based optimal energy assessment of hybrid multi-effect evaporator with synergy of solar and wind energy sources.

Background: The increasing complexity of basketball and the need for optimal decision-making in order to maximize competitive performance highlight the necessity of specialized training for basketball coaches. This systematic review aims to compile, synthesize, and integrate international research published in specialized journals on the training of basketball coaches and students, examining their characteristics and needs. Specifically, it analyzes the content, technical-tactical actions, and methodologies used in practice and education programs to determine which essential parameters for their technical and tactical development. Methods: A structured search was carried out following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA®) guidelines and the PICOS® model until January 30, 2025, in the MEDLINE/PubMed, Web of Science (WOS), ScienceDirect, Cochrane Library, SciELO, EMBASE, SPORTDiscus, and Scopus databases. The risk of bias was assessed and the PEDro scale was used to analyze methodological quality. Results: A total of 14,090 articles were obtained in the initial search. After inclusion and exclusion criteria, the final sample was 23 articles. These studies maintained a high standard of quality. This revealed data on the technical-tactical actions addressed in different categories; the profiles, characteristics, and influence of coaches on player development; and the approaches, teaching methods, and evaluation methodologies used in acquiring knowledge and competencies for the professional development of basketball coaches. Conclusions: Adequate theoretical and practical training for basketball coaches is essential for player development. Therefore, training programs for basketball coaches must integrate technical-tactical, physical, and psychological knowledge with the acquisition of skills and competencies that are refined through practice. This training should be continuous, more specialized, and comprehensive, focusing on understanding and constructing knowledge that supports the professional growth of basketballers. Additionally, training should incorporate digital tools and informal learning opportunities, with blended learning emerging as the most effective methodology for this purpose.

Methodology and content for the design of basketball coach education programs: a systematic review.

Polyphenols are naturally occurring compounds that can be found in plant-based foods, including fruits, vegetables, nuts, seeds, herbs, spices, and beverages, the use of which has been linked to enhanced brain health and cognitive function. These natural molecules are broadly classified into two main groups: flavonoids and non-flavonoid polyphenols, the latter including phenolic acids, stilbenes, and tannins. Flavonoids are primarily known for their potent antioxidant properties, which help neutralize harmful reactive oxygen species (ROS) in the brain, thereby reducing oxidative stress, a key contributor to neurodegenerative diseases. In addition to their antioxidant effects, flavonoids have been shown to modulate inflammation, enhance neuronal survival, and support neurogenesis, all of which are critical for maintaining cognitive function. Phenolic acids possess strong antioxidant properties and are believed to protect brain cells from oxidative damage. Neuroprotective effects of these molecules can also depend on their ability to modulate signaling pathways associated with inflammation and neuronal apoptosis. Among polyphenols, hydroxycinnamic acids such as caffeic acid have been shown to enhance blood-brain barrier permeability, which may increase the delivery of other protective compounds to the brain. Another compound of interest is represented by resveratrol, a stilbene extensively studied for its potential neuroprotective properties related to its ability to activate the sirtuin pathway, a molecular signaling pathway involved in cellular stress response and aging. Lignans, on the other hand, have shown promise in reducing neuroinflammation and oxidative stress, which could help slow the progression of neurodegenerative diseases and cognitive decline. Polyphenols belonging to different subclasses, such as flavonoids, phenolic acids, stilbenes, and lignans, exert neuroprotective effects by regulating microglial activation, suppressing pro-inflammatory cytokines, and mitigating oxidative stress. These compounds act through multiple signaling pathways, including NF-κB, MAPK, and Nrf2, and they may also influence genetic regulation of inflammation and immune responses at brain level. Despite their potential for brain health and cognitive function, polyphenols are often characterized by low bioavailability, something that deserves attention when considering their therapeutic potential. Future translational studies are needed to better understand the right dosage, the overall diet, the correct target population, as well as ideal formulations allowing to overcome bioavailability limitations.

Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function.

Novel Transfer Learning Approach for Detecting Infected and Healthy Maize Crop Using Leaf Images.

Novel transfer learning approach for hand drawn mathematical geometric shapes classification.

Novel transfer learning based bone fracture detection using radiographic images.

Nut Consumption Is Associated with Cognitive Status in Southern Italian Adults.

On the correlation between Google Play Store application icons and downloads.

Pupilometer efficacy in monitoring anxiety in undergraduate medical students during high-fidelity clinical simulation.

Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations.

Socio-economic status, food security and adherence to the Mediterranean diet in five Mediterranean countries: the DELICIOUS project.

Strawberry as a health promoter: an evidence-based review. Where are we 10 years later?

Background: Scientific research should be carried out to prevent sports injuries. For this purpose, new assessment technologies must be used to analyze and identify the risk factors for injury. The main objective of this systematic review was to compile, synthesize and integrate international research published in different scientific databases on Countermovement Jump (CMJ), Functional Movement Screen (FMS) and Tensiomyography (TMG) tests and technologies for the assessment of injury risk in sport. This way, this review determines the current state of the knowledge about this topic and allows a better understanding of the existing problems, making easier the development of future lines of research. Methodology: A structured search was carried out following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines and the PICOS model until November 30, 2024, in the MEDLINE/PubMed, Web of Science (WOS), ScienceDirect, Cochrane Library, SciELO, EMBASE, SPORTDiscus and Scopus databases. The risk of bias was assessed and the PEDro scale was used to analyze methodological quality. Results: A total of 510 articles were obtained in the initial search. After inclusion and exclusion criteria, the final sample was 40 articles. These studies maintained a high standard of quality. This revealed the effects of the CMJ, FMS and TMG methods for sports injury assessment, indicating the sample population, sport modality, assessment methods, type of research design, study variables, main findings and intervention effects. Conclusions: The CMJ vertical jump allows us to evaluate the power capacity of the lower extremities, both unilaterally and bilaterally, detect neuromuscular asymmetries and evaluate fatigue. Likewise, FMS could be used to assess an athlete's basic movement patterns, mobility and postural stability. Finally, TMG is a non-invasive method to assess the contractile properties of superficial muscles, monitor the effects of training, detect muscle asymmetries, symmetries, provide information on muscle tone and evaluate fatigue. Therefore, they should be considered as assessment tests and technologies to individualize training programs and identify injury risk factors.

Tensiomyography, functional movement screen and counter movement jump for the assessment of injury risk in sport: a systematic review of original studies of diagnostic tests.

Ultra Wideband radar-based gait analysis for gender classification using artificial intelligence.

Unhealthy Ultra-Processed Food, Diet Quality and Adherence to the Mediterranean Diet in Children and Adolescents: The DELICIOUS Project.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease driven by persistent inflammation and oxidative stress. Ilex paraguariensis (yerba mate) contains bioactive compounds—particularly chlorogenic acids, quercetin, and rutin—with documented antioxidant and anti-inflammatory properties. Objectives: To systematically review the mechanistic and clinical evidence on Ilex paraguariensis and its main constituents in RA-relevant inflammatory, oxidative, and bone metabolic pathways. Methods: Following PRISMA 2020, PubMed/MEDLINE, LILACS, and SciELO were searched up to September 2025. Eligible studies included yerba mate preparations (last 10 years) or isolated compounds (last 5 years) assessing RA-relevant clinical, inflammatory, oxidative, or bone metabolic outcomes. Non-original studies were excluded. Owing to heterogeneity, findings were narratively synthesized, and risk of bias was evaluated using RoB 2, ROBINS-I, OHAT, and SYRCLE. Results: Twenty-three studies met inclusion criteria: 11 human (clinical or observational), 7 human-based in vitro, and 5 animal studies. Interventions with yerba mate infusions or standardized extracts suggest reductions in inflammatory markers (e.g., C-reactive protein, interleukin-6) and indicate improvements in glutathione-related oxidative balance. Evidence from isolated compounds, particularly quercetin and rutin, suggests comparable anti-inflammatory and antioxidant effects. Preclinical studies appear to indicate modulation of inflammatory and redox pathways relevant to RA. Conclusions: Yerba mate and its constituents show preliminary indications of anti-inflammatory and antioxidant effects with potential relevance to RA pathophysiology. However, in the absence of clinical trials in RA patients, conclusions remain tentative, constrained by small sample sizes, methodological heterogeneity, species differences, and internal validity concerns. Future research should include rigorously designed randomized trials and mechanistic studies using advanced human-relevant platforms, such as organoids and organ-on-chip systems.

Yerba Mate (Ilex paraguariensis) and Rheumatoid Arthritis: A Systematic Review of Mechanistic and Clinical Evidence.

A systematic review of deep learning methods for community detection in social networks.

2024

Advancement in medical report generation: current practices, challenges, and future directions.

Carotenoids Intake and Cardiovascular Prevention: A Systematic Review.

Clinical phenotypes and short-term outcomes based on prehospital point-of-care testing and on-scene vital signs.

A Comparison of the Clinical Characteristics of Short-, Mid-, and Long-Term Mortality in Patients Attended by the Emergency Medical Services: An Observational Study.

Decoding Brain Signals from Rapid-Event EEG for Visual Analysis Using Deep Learning.

Deep Learning Approaches for Image Captioning: Opportunities, Challenges and Future Potential.

Diagnosing epileptic seizures using combined features from independent components and prediction probability from EEG data.

Efficient deep learning-based approach for malaria detection using red blood cell smears.

Enhanced detection of diabetes mellitus using novel ensemble feature engineering approach and machine learning model.

Enhanced interpretable thyroid disease diagnosis by leveraging synthetic oversampling and machine learning models.

Evolving epidemiology, clinical features, and genotyping of dengue outbreaks in Bangladesh, 2000–2024: a systematic review.

Exploring the Potential of Microservices in Internet of Things: A Systematic Review of Security and Prospects.

In contemporary society, depression has emerged as a prominent mental disorder that exhibits exponential growth and exerts a substantial influence on premature mortality. Although numerous research applied machine learning methods to forecast signs of depression. Nevertheless, only a limited number of research have taken into account the severity level as a multiclass variable. Besides, maintaining the equality of data distribution among all the classes rarely happens in practical communities. So, the inevitable class imbalance for multiple variables is considered a substantial challenge in this domain. Furthermore, this research emphasizes the significance of addressing class imbalance issues in the context of multiple classes. We introduced a new approach Feature group partitioning (FGP) in the data preprocessing phase which effectively reduces the dimensionality of features to a minimum. This study utilized synthetic oversampling techniques, specifically Synthetic Minority Over-sampling Technique (SMOTE) and Adaptive Synthetic (ADASYN), for class balancing. The dataset used in this research was collected from university students by administering the Burn Depression Checklist (BDC). For methodological modifications, we implemented heterogeneous ensemble learning stacking, homogeneous ensemble bagging, and five distinct supervised machine learning algorithms. The issue of overfitting was mitigated by evaluating the accuracy of the training, validation, and testing datasets. To justify the effectiveness of the prediction models, balanced accuracy, sensitivity, specificity, precision, and f1-score indices are used. Overall, comprehensive analysis demonstrates the discrimination between the Conventional Depression Screening (CDS) and FGP approach. In summary, the results show that the stacking classifier for FGP with SMOTE approach yields the highest balanced accuracy, with a rate of 92.81%. The empirical evidence has demonstrated that the FGP approach, when combined with the SMOTE, able to produce better performance in predicting the severity of depression. Most importantly the optimization of the training time of the FGP approach for all of the classifiers is a significant achievement of this research.

Feature group partitioning: an approach for depression severity prediction with class balancing using machine learning algorithms.

Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action.

Investigation of structural frustration in symmetric diblock copolymers confined in polar discs through cell dynamic simulation.

Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?

Lifestyle Factors Associated with Children’s and Adolescents’ Adherence to the Mediterranean Diet Living in Mediterranean Countries: The DELICIOUS Project.

Mediterranean Diet and Sleep Features: A Systematic Review of Current Evidence.

Natural Language Processing-Based Software Testing: A Systematic Literature Review.

Organizational Culture Assessment Based on a Values-Based Coaching Program for Strategic Level Employees: The Case of GEDEME, Cuba.

Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments.

PyDEMATEL: A Python-based tool implementing DEMATEL and fuzzy DEMATEL methods for improved decision making.

Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained particular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for modulating the biological activities of phenolic metabolites in humans. The present review aims to summarize the main findings from clinical trials on the effects of resveratrol interventions on endothelial and vascular outcomes and review potential mechanisms interesting the role of gut microbiota on the metabolism of this molecule and its cardioprotective metabolites. The findings from randomized controlled trials show contrasting results on the effects of resveratrol supplementation and vascular biomarkers without dose-dependent effect. In particular, studies in which resveratrol was integrated using food sources, i.e., red wine, reported significant effects although the resveratrol content was, on average, much lower compared to tablet supplementation, while other studies with often extreme resveratrol supplementation resulted in null findings. The results from experimental studies suggest that resveratrol exerts cardioprotective effects through the modulation of various antioxidant, anti-inflammatory, and anti-hypertensive pathways, and microbiota composition. Recent studies on resveratrol-derived metabolites, such as piceatannol, have demonstrated its effects on biomarkers of vascular health. Moreover, resveratrol itself has been shown to improve the gut microbiota composition toward an anti-inflammatory profile. Considering the contrasting findings from clinical studies, future research exploring the bidirectional link between resveratrol metabolism and gut microbiota as well as the mediating effect of gut microbiota in resveratrol effect on cardiovascular health is warranted.

Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota.

Risk Factors for Eating Disorders in University Students: The RUNEAT Study.

Roman urdu hate speech detection using hybrid machine learning models and hyperparameter optimization.

Smart Physiotherapy: Advancing Arm-Based Exercise Classification with PoseNet and Ensemble Models.

Plant stress reduction research has advanced significantly with the use of Artificial Intelligence (AI) techniques, such as machine learning and deep learning. This is a significant step toward sustainable agriculture. Innovative insights into the physiological responses of plants mostly crops to drought stress have been revealed through the use of complex algorithms like gradient boosting, support vector machines (SVM), recurrent neural network (RNN), and long short-term memory (LSTM), combined with a thorough examination of the TYRKC and RBR-E3 domains in stress-associated signaling proteins across a range of crop species. Modern resources were used in this study, including the UniProt protein database for crop physiochemical properties associated with specific signaling domains and the SMART database for signaling protein domains. These insights were then applied to deep learning and machine learning techniques after careful data processing. The rigorous metric evaluations and ablation analysis that typified the study’s approach highlighted the algorithms’ effectiveness and dependability in recognizing and classifying stress events. Notably, the accuracy of SVM was 82%, while gradient boosting and RNN showed 96%, and 94%, respectively and LSTM obtained an astounding 97% accuracy. The study observed these successes but also highlights the ongoing obstacles to AI adoption in agriculture, emphasizing the need for creative thinking and interdisciplinary cooperation. In addition to its scholarly value, the collected data has significant implications for improving resource efficiency, directing precision agricultural methods, and supporting global food security programs. Notably, the gradient boosting and LSTM algorithm outperformed the others with an exceptional accuracy of 96% and 97%, demonstrating their potential for accurate stress categorization. This work highlights the revolutionary potential of AI to completely disrupt the agricultural industry while simultaneously advancing our understanding of plant stress responses.

Smart agriculture: utilizing machine learning and deep learning for drought stress identification in crops.

Ultra-Wide Band Radar Empowered Driver Drowsiness Detection with Convolutional Spatial Feature Engineering and Artificial Intelligence.

Underwater Thermal Energy Harvesting: Frameworks, Challenges, Applications, and Future Investigation.

Virtual histopathology methods in medical imaging - a systematic review.

A deep learning approach to optimize remaining useful life prediction for Li-ion batteries.

An improved deep convolutional neural network-based YouTube video classification using textual features.

2023

Prehospital acute life-threatening cardiovascular disease in elderly: an observational, prospective, multicentre, ambulance-based cohort study.

Introduction: Rotavirus infection is a major cause of mortality among children under 5 years in Bangladesh. There is lack of integrated studies on rotavirus prevalence and genetic diversity during 1973 to 2023 in Bangladesh. Methods: This meta-analysis was conducted to determine the prevalence, genotypic diversity and seasonal distribution of rotavirus during pre-vaccination period in Bangladesh. This study included published articles on rotavirus A, rotavirus B and rotavirus C. We used Medline, Scopus and Google Scholar for published articles. Selected literatures were published between 1973 to 2023. Results: This study detected 12431 research articles published on rotavirus. Based on the inclusion criteria, 29 of 75 (30.2%) studies were selected. Molecular epidemiological data was taken from 29 articles, prevalence data from 29 articles, and clinical symptoms from 19 articles. The pooled prevalence of rotavirus was 30.1% (95% CI: 22%-45%, p = 0.005). Rotavirus G1 (27.1%, 2228 of 8219) was the most prevalent followed by G2 (21.09%, 1733 of 8219), G4 (11.58%, 952 of 8219), G9 (9.37%, 770 of 8219), G12 (8.48%, 697 of 8219), and G3 (2.79%, 229 of 8219), respectively. Genotype P[8] (40.6%, 2548 of 6274) was the most prevalent followed by P[4] (12.4%, 777 of 6274) and P[6] (6.4%, 400 of 6274), respectively. Rotavirus G1P[8] (19%) was the most frequent followed by G2P [4] (9.4%), G12P[8] (7.2%), and G9P[8], respectively. Rotavirus infection had higher odds of occurrence during December and February (aOR: 2.86, 95% CI: 2.43-3.6, p = 0.001). Discussion: This is the first meta-analysis including all the studies on prevalence, molecular epidemiology, and genetic diversity of rotavirus from 1973 to 2023, pre-vaccination period in Bangladesh. This study will provide overall scenario of rotavirus genetic diversity and seasonality during pre-vaccination period and aids in policy making for rotavirus vaccination program in Bangladesh. This work will add valuable knowledge for vaccination against rotavirus and compare the data after starting vaccination in Bangladesh.

Prevalence and genetic diversity of rotavirus in Bangladesh during pre-vaccination period, 1973-2023: a meta-analysis.

Software Cost and Effort Estimation: Current Approaches and Future Trends.

Data mining is an analytical approach that contributes to achieving a solution to many problems by extracting previously unknown, fascinating, nontrivial, and potentially valuable information from massive datasets. Clustering in data mining is used for splitting or segmenting data items/points into meaningful groups and clusters by grouping the items that are near to each other based on certain statistics. This paper covers various elements of clustering, such as algorithmic methodologies, applications, clustering assessment measurement, and researcher-proposed enhancements with their impact on data mining thorough grasp of clustering algorithms, its applications, and the advances achieved in the existing literature. This study includes a literature search for papers published between 1995 and 2023, including conference and journal publications. The study begins by outlining fundamental clustering techniques along with algorithm improvements and emphasizing their advantages and limitations in comparison to other clustering algorithms. It investigates the evolution measures for clustering algorithms with an emphasis on metrics used to gauge clustering quality, such as the F-measure and the Rand Index. This study includes a variety of clustering-related topics, such as algorithmic approaches, practical applications, metrics for clustering evaluation, and researcher-proposed improvements. It addresses numerous methodologies offered to increase the convergence speed, resilience, and accuracy of clustering, such as initialization procedures, distance measures, and optimization strategies. The work concludes by emphasizing clustering as an active research area driven by the need to identify significant patterns and structures in data, enhance knowledge acquisition, and improve decision making across different domains. This study aims to contribute to the broader knowledge base of data mining practitioners and researchers, facilitating informed decision making and fostering advancements in the field through a thorough analysis of algorithmic enhancements, clustering assessment metrics, and optimization strategies.

A Systematic Literature Review on Identifying Patterns Using Unsupervised Clustering Algorithms: A Data Mining Perspective.

A Systematic Survey of AI Models in Financial Market Forecasting for Profitability Analysis.