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2023

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Background: Nowadays, there is no gold standard score for prehospital sepsis and sepsis-related mortality identification. The aim of the present study was to analyze the performance of qSOFA, NEWS2 and mSOFA as sepsis predictors in patients with infection-suspected in prehospital care. The second objective is to study the predictive ability of the aforementioned scores in septic-shock and in-hospital mortality. Methods: Prospective, ambulance-based, and multicenter cohort study, developed by the emergency medical services, among patients (n = 535) with suspected infection transferred by ambulance with high-priority to the emergency department (ED). The study enrolled 40 ambulances and 4 ED in Spain between 1 January 2020, and 30 September 2021. All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. For the evaluation of the scores, the discriminative power, calibration curve and decision curve analysis (DCA) were used. Results: The mSOFA outperformed the other two scores for mortality, presenting the following AUCs: 0.877 (95%CI 0.841–0.913), 0.761 (95%CI 0.706–0.816), 0.731 (95%CI 0.674–0.788), for mSOFA, NEWS, and qSOFA, respectively. No differences were found for sepsis nor septic shock, but mSOFA’s AUCs was higher than the one of the other two scores. The calibration curve and DCA presented similar results. Conclusion: The use of mSOFA could provide and extra insight regarding the short-term mortality and sepsis diagnostic, backing its recommendation in the prehospital scenario. metadata Melero-Guijarro, Laura and Sanz-García, Ancor and Martín-Rodríguez, Francisco and Lipari, Vivian and Mazas Pérez-Oleaga, Cristina and Carvajal-Altamiranda, Stefanía and Martínez López, Nohora Milena and Dominguez Azpíroz, Irma and Castro Villamor, Miguel A. and Sánchez Soberón, Irene and López-Izquierdo, Raúl mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, cristina.mazas@uneatlantico.es, stefania.carvajal@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2023) Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study. Frontiers in Medicine, 10. ISSN 2296-858X

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Mutations allow viruses to continuously evolve by changing their genetic code to adapt to the hosts they infect. It is an adaptive and evolutionary mechanism that helps viruses acquire characteristics favoring their survival and propagation. The COVID-19 pandemic declared by the WHO in March 2020 is caused by the SARS-CoV-2 virus. The non-stop adaptive mutations of this virus and the emergence of several variants over time with characteristics favoring their spread constitute one of the biggest obstacles that researchers face in controlling this pandemic. Understanding the mutation mechanism allows for the adoption of anticipatory measures and the proposal of strategies to control its propagation. In this study, we focus on the mutations of this virus, and we propose the SARSMutOnto ontology to model SARS-CoV-2 mutations reported by Pango researchers. A detailed description is given for each mutation. The genes where the mutations occur and the genomic structure of this virus are also included. The sub-lineages and the recombinant sub-lineages resulting from these mutations are additionally represented while maintaining their hierarchy. We developed a Python-based tool to automatically generate this ontology from various published Pango source files. At the end of this paper, we provide some examples of SPARQL queries that can be used to exploit this ontology. SARSMutOnto might become a ‘wet bench’ machine learning tool for predicting likely future mutations based on previous mutations. metadata Bakkas, Jamal and Hanine, Mohamed and Chekry, Abderrahman and Gounane, Said and de la Torre Díez, Isabel and Lipari, Vivian and Martínez López, Nohora Milena and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, nohora.martinez@uneatlantico.es, UNSPECIFIED (2023) SARSMutOnto: An Ontology for SARS-CoV-2 Lineages and Mutations. Viruses, 15 (2). p. 505. ISSN 1999-4915

Article Subjects > Biomedicine
Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Obesity and overweight has increased in the last year and has become a pandemic disease, the result of sedentary lifestyles and unhealthy diets rich in sugars, refined starches, fats and calories. Machine learning (ML) has proven to be very useful in the scientific community, especially in the health sector. With the aim of providing useful tools to help nutritionists and dieticians, research focused on the development of ML and Deep Learning (DL) algorithms and models is searched in the literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol has been used, a very common technique applied to carry out revisions. In our proposal, 17 articles have been filtered in which ML and DL are applied in the prediction of diseases, in the delineation of treatment strategies, in the improvement of personalized nutrition and more. Despite expecting better results with the use of DL, according to the selected investigations, the traditional methods are still the most used and the yields in both cases fluctuate around positive values, conditioned by the databases (transformed in each case) to a greater extent than by the artificial intelligence paradigm used. Conclusions: An important compilation is provided for the literature in this area. ML models are time-consuming to clean data, but (like DL) they allow automatic modeling of large volumes of data which makes them superior to traditional statistics. metadata Ferreras, Antonio and Sumalla Cano, Sandra and Martínez-Licort, Rosmeri and Elío Pascual, Iñaki and Tutusaus, Kilian and Prola, Thomas and Vidal Mazón, Juan Luis and Sahelices, Benjamín and de la Torre Díez, Isabel mail UNSPECIFIED, sandra.sumalla@uneatlantico.es, UNSPECIFIED, inaki.elio@uneatlantico.es, kilian.tutusaus@uneatlantico.es, thomas.prola@uneatlantico.es, juanluis.vidal@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) Systematic Review of Machine Learning applied to the Prediction of Obesity and Overweight. Journal of Medical Systems, 47 (1). ISSN 1573-689X

2022

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Asthma is a deadly disease that affects the lungs and air supply of the human body. Coronavirus and its variants also affect the airways of the lungs. Asthma patients approach hospitals mostly in a critical condition and require emergency treatment, which creates a burden on health institutions during pandemics. The similar symptoms of asthma and coronavirus create confusion for health workers during patient handling and treatment of disease. The unavailability of patient history to physicians causes complications in proper diagnostics and treatments. Many asthma patient deaths have been reported especially during pandemics, which necessitates an efficient framework for asthma patients. In this article, we have proposed a blockchain consortium healthcare framework for asthma patients. The proposed framework helps in managing asthma healthcare units, coronavirus patient records and vaccination centers, insurance companies, and government agencies, which are connected through the secure blockchain network. The proposed framework increases data security and scalability as it stores encrypted patient data on the Interplanetary File System (IPFS) and keeps data hash values on the blockchain. The patient data are traceable and accessible to physicians and stakeholders, which helps in accurate diagnostics, timely treatment, and the management of patients. The smart contract ensures the execution of all business rules. The patient profile generation mechanism is also discussed. The experiment results revealed that the proposed framework has better transaction throughput, query delay, and security than existing solutions metadata Farooq, Muhammad Shoaib and Suhail, Maryam and Qureshi, Junaid Nasir and Rustam, Furqan and de la Torre Díez, Isabel and Vidal Mazón, Juan Luis and Rodríguez Velasco, Carmen Lilí and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, UNSPECIFIED (2022) Consortium Framework Using Blockchain for Asthma Healthcare in Pandemics. Sensors, 22 (21). p. 8582. ISSN 1424-8220

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Español Patient care and convenience remain the concern of medical professionals and caregivers alike. An unconscious patient confined to a bed may develop fluid accumulation and pressure sores due to inactivity and deficiency of oxygen flow. Moreover, weight monitoring is crucial for an effective treatment plan, which is difficult to measure for bedridden patients. This paper presents the design and development of a smart and cost-effective independent system for lateral rotation, movement, weight measurement, and transporting immobile patients. Optimal dimensions and practical design specifications are determined by a survey across various hospitals. Subsequently, the proposed hoist-based weighing and turning mechanism is CAD-modeled and simulated. Later, the structural analysis is carried out to select suitable metallurgy for various sub-assemblies to ensure design reliability. After fabrication, optimization, integration, and testing procedures, the base frame is designed to mount a hydraulic motor for the actuator, a DC power source for self-sustenance, and lockable wheels for portability. The installation of a weighing scale and a hydraulic actuator is ensured to lift the patient for weight measuring up to 600 pounds or lateral turning of 80 degrees both ways. The developed system offers simple operating characteristics, allows for keeping patient weight records, and assists nurses in changing patients’ lateral positions both ways, comfortably massage patients’ backs, and transport them from one bed to another. Additionally, being lightweight offers reduced contact with the patient to increase the healthcare staff’s safety in pandemics; it is also height adjustable and portable, allowing for use with multiple-sized beds and easy transportation across the medical facility. The feedback from paramedics is encouraging regarding reducing labor-intensive nursing tasks, alleviating the discomfort of long-term bed-ridden patients, and allowing medical practitioners to suggest better treatment plans metadata Shafi, Imran and Farooq, Muhammad Siddique and De La Torre Díez, Isabel and Breñosa, Jose and Martínez Espinosa, Julio César and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, UNSPECIFIED (2022) Design and Development of Smart Weight Measurement, Lateral Turning and Transfer Bedding for Unconscious Patients in Pandemics. Healthcare, 10 (11). p. 2174. ISSN 2227-9032

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés The diagnosis of early-stage lung cancer is challenging due to its asymptomatic nature, especially given the repeated radiation exposure and high cost of computed tomography(CT). Examining the lung CT images to detect pulmonary nodules, especially the cell lung cancer lesions, is also tedious and prone to errors even by a specialist. This study proposes a cancer diagnostic model based on a deep learning-enabled support vector machine (SVM). The proposed computer-aided design (CAD) model identifies the physiological and pathological changes in the soft tissues of the cross-section in lung cancer lesions. The model is first trained to recognize lung cancer by measuring and comparing the selected profile values in CT images obtained from patients and control patients at their diagnosis. Then, the model is tested and validated using the CT scans of both patients and control patients that are not shown in the training phase. The study investigates 888 annotated CT scans from the publicly available LIDC/IDRI database. The proposed deep learning-assisted SVM-based model yields 94% accuracy for pulmonary nodule detection representing early-stage lung cancer. It is found superior to other existing methods including complex deep learning, simple machine learning, and the hybrid techniques used on lung CT images for nodule detection. Experimental results demonstrate that the proposed approach can greatly assist radiologists in detecting early lung cancer and facilitating the timely management of patients. metadata Shafi, Imran and Din, Sadia and Khan, Asim and Díez, Isabel De La Torre and Pali-Casanova, Ramón and Tutusaus, Kilian and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ramon.pali@unini.edu.mx, kilian.tutusaus@uneatlantico.es, UNSPECIFIED (2022) An Effective Method for Lung Cancer Diagnosis from CT Scan Using Deep Learning-Based Support Vector Network. Cancers, 14 (21). p. 5457. ISSN 2072-6694

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Mobility and low energy consumption are considered the main requirements for wireless body area sensor networks (WBASN) used in healthcare monitoring systems (HMS). In HMS, battery-powered sensor nodes with limited energy are used to obtain vital statistics about the body. Hence, energy-efficient schemes are desired to maintain long-term and steady connectivity of the sensor nodes. A sheer amount of energy is consumed in activities such as idle listening, excessive transmission and reception of control messages, packet collisions and retransmission of packets, and poor path selection, that may lead to more energy consumption. A combination of adaptive scheduling with an energy-efficient protocol can help select an appropriate path at a suitable time to minimize the control overhead, energy consumption, packet collision, and excessive idle listening. This paper proposes a region-based energy-efficient multipath routing (REMR) approach that divides the entire sensor network into clusters with preferably multiple candidates to represent each cluster. The cluster representatives (CRs) route packets through various clusters. For routing, the energy requirement of each route is considered, and the path with minimum energy requirements is selected. Similarly, end-to-end delay, higher throughput, and packet-delivery ratio are considered for packet routing. metadata Akbar, Shuja and Mehdi, Muhammad Mohsin and Jamal, M. Hasan and Raza, Imran and Hussain, Syed Asad and Breñosa, Jose and Martínez Espinosa, Julio César and Pascual Barrera, Alina Eugenia and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, alina.pascual@unini.edu.mx, UNSPECIFIED (2022) Multipath Routing in Wireless Body Area Sensor Network for Healthcare Monitoring. Healthcare, 10 (11). p. 2297. ISSN 2227-9032

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés The prevalence of anxiety among university students is increasing, resulting in the negative impact on their academic and social (behavioral and emotional) development. In order for students to have competitive academic performance, the cognitive function should be strengthened by detecting and handling anxiety. Over a period of 6 weeks, this study examined how to detect anxiety and how Mano Shakti Yoga (MSY) helps reduce anxiety. Relying on cardiac signals, this study follows an integrated detection-estimation-reduction framework for anxiety using the Intelligent Internet of Medical Things (IIoMT) and MSY. IIoMT is the integration of Internet of Medical Things (wearable smart belt) and machine learning algorithms (Decision Tree (DT), Random Forest (RF), and AdaBoost (AB)). Sixty-six eligible students were selected as experiencing anxiety detected based on the results of self-rating anxiety scale (SAS) questionnaire and a smart belt. Then, the students were divided randomly into two groups: experimental and control. The experimental group followed an MSY intervention for one hour twice a week, while the control group followed their own daily routine. Machine learning algorithms are used to analyze the data obtained from the smart belt. MSY is an alternative improvement for the immune system that helps reduce anxiety. All the results illustrate that the experimental group reduced anxiety with a significant (p < 0.05) difference in group × time interaction compared to the control group. The intelligent techniques achieved maximum accuracy of 80% on using RF algorithm. Thus, students can practice MSY and concentrate on their objectives by improving their intelligence, attention, and memory. metadata Pal, Rishi and Adhikari, Deepak and Heyat, Md Belal Bin and Guragai, Bishal and Lipari, Vivian and Brito Ballester, Julién and De la Torre Díez, Isabel and Abbas, Zia and Lai, Dakun mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, julien.brito@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) A Novel Smart Belt for Anxiety Detection, Classification, and Reduction Using IIoMT on Students’ Cardiac Signal and MSY. Bioengineering, 9 (12). p. 793. ISSN 2306-5354

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. metadata Armas Diaz, Yasmany and Machì, Michele and Salinari, Alessia and Mazas Pérez-Oleaga, Cristina and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Cianciosi, Danila mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, UNSPECIFIED (2022) Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet. Mediterranean Journal of Nutrition and Metabolism, 15 (4). pp. 581-592. ISSN 1973798X

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Herbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectiveness in alleviating premenstrual symptoms. The published randomized controlled trials (RCTs) were extracted from Google scholar, PubMed, Scopus and PROSPERO databases. The risk of bias in randomized trials was assessed by Cochrane risk-of-bias tool. The main outcome parameters were analysed separately based on the Premenstrual Symptom Screening Tool and PMTS and DRSP scores. Secondary parameters of somatic, psychological, and behavioural subscale symptoms of PSST were also analysed. Data synthesis was performed assuming a random-effects model, and standardized mean difference (SMDs) was analysed using SPSS version 28.0.0 (IBM, Armonk, NY, USA). A total of 754 articles were screened, and 15 RCTs were included (n = 1211 patients). Primary results for participants randomized to an intervention reported reduced PSST (n = 9), PMTS (n = 2), and DSR (n = 4) scores with (SMD = −1.44; 95% CI: −1.72 to −1.17), (SMD = −1.69; 95% CI: −3.80 to 0.42) and (SMD = 2.86; 95% CI: 1.02 to 4.69) verses comparator with substantial heterogeneity. Physical (SMD = −1.61; 95% CI = −2.56 to −0.66), behavioural (SMD = −0.60; 95% CI = −1.55 to0.35) and mood (SMD = 0.57; 95% CI = −0.96 to 2.11) subscale symptom groupings of PSST displayed similar findings. Fifty-three studies (n = 8) were considered at low risk of bias with high quality. Mild adverse events were reported by four RCTs. Based on the existing evidence, herbal medicine and nutritional supplements may be effective and safe for PMS metadata Sultana, Arshiya and Heyat, Md Belal Bin and Rahman, Khaleequr and Kunnavil, Radhika and Fazmiya, Mohamed Joonus Aynul and Akhtar, Faijan and Sumbul, X. and Vidal Mazón, Juan Luis and Rodríguez Velasco, Carmen Lilí and De La Torre Díez, Isabel mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, UNSPECIFIED (2022) A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements. Pharmaceuticals, 15 (11). p. 1371. ISSN 1424-8247

Article Subjects > Biomedicine
Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Magazines
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés White blood cell (WBC) type classification is a task of significant importance for diagnosis using microscopic images of WBC, which develop immunity to fight against infections and foreign substances. WBCs consist of different types, and abnormalities in a type of WBC may potentially represent a disease such as leukemia. Existing studies are limited by low accuracy and overrated performance, often caused by model overfit due to an imbalanced dataset. Additionally, many studies consider a lower number of WBC types, and the accuracy is exaggerated. This study presents a hybrid feature set of selective features and synthetic minority oversampling technique-based resampling to mitigate the influence of the above-mentioned problems. Furthermore, machine learning models are adopted for being less computationally complex, requiring less data for training, and providing robust results. Experiments are performed using both machine- and deep learning models for performance comparison using the original dataset, augmented dataset, and oversampled dataset to analyze the performances of the models. The results suggest that a hybrid feature set of both texture and RGB features from microscopic images, selected using Chi2, produces a high accuracy of 0.97 with random forest. Performance appraisal using k-fold cross-validation and comparison with existing state-of-the-art studies shows that the proposed approach outperforms existing studies regarding the obtained accuracy and computational complexity. metadata Rustam, Furqan and Aslam, Naila and De La Torre Díez, Isabel and Khan, Yaser Daanial and Vidal Mazón, Juan Luis and Rodríguez Velasco, Carmen Lilí and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, UNSPECIFIED (2022) White Blood Cell Classification Using Texture and RGB Features of Oversampled Microscopic Images. Healthcare, 10 (11). p. 2230. ISSN 2227-9032

2020

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate cancer immunosurveillance, reducing the migration of immunosuppressive regulatory T cells towards the tumor bulk. Autophagy stimulation via reduction of lysine acetylation, increased sensitivity to chemo- and immunotherapy, along with a reduction of insulin-like growth factor 1 and reactive oxygen species have been described as some of the major effects triggered by caloric restriction. Fasting and caloric restriction have also been shown to beneficially influence gut microbiota composition, modify host metabolism, reduce total cholesterol and triglyceride levels, lower diastolic blood pressure and elevate morning cortisol level, with beneficial modulatory effects on cardiopulmonary fitness, body fat and weight, fatigue and weakness, and general quality of life. Moreover, caloric restriction may reduce the carcinogenic and metastatic potential of cancer stem cells, which are generally considered responsible of tumor formation and relapse. Here, we reviewed in vitro and in vivo studies describing the effects of fasting, caloric restriction and some caloric restriction mimetics on immunosurveillance, gut microbiota, metabolism, and cancer stem cell growth, highlighting the molecular and cellular mechanisms underlying these effects. Additionally, studies on caloric restriction interventions in cancer patients or cancer risk subjects are discussed. Considering the promising effects associated with caloric restriction and caloric restriction mimetics, we think that controlled-randomized large clinical trials are warranted to evaluate the inclusion of these non-pharmacological approaches in clinical practice. metadata Pistollato, Francesca and Forbes-Hernández, Tamara Y. and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Elexpuru Zabaleta, Maria and Dominguez Azpíroz, Irma and Cianciosi, Danila and Quiles, José L. and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, maria.elexpuru@uneatlantico.es, irma.dominguez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2020) Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment. Seminars in Cancer Biology. ISSN 1044-579X

This list was generated on Sun Jun 4 19:53:03 2023 UTC.

open

Deep Learning-Based Real Time Defect Detection for Optimization of Aircraft Manufacturing and Control Performance

Monitoring tool conditions and sub-assemblies before final integration is essential to reducing processing failures and improving production quality for manufacturing setups. This research study proposes a real-time deep learning-based framework for identifying faulty components due to malfunctioning at different manufacturing stages in the aerospace industry. It uses a convolutional neural network (CNN) to recognize and classify intermediate abnormal states in a single manufacturing process. The manufacturing process for aircraft factory products comprises different phases; analyzing the components after the integration is labor-intensive and time-consuming, which often puts the company’s stake at high risk. To overcome these challenges, the proposed AI-based system can perform inspection and defect detection and alleviate the probability of components’ needing to be re-manufacturing after being assembled. In addition, it analyses the impact value, i.e., rework delays and costs, of manufacturing processes using a statistical process control tool on real-time data for various manufactured components. Defects are detected and classified using the CNN and teachable machine in the single manufacturing process during the initial stage prior to assembling the components. The results show the significance of the proposed approach in improving operational cost management and reducing rework-induced delays. Ground tests are conducted to calculate the impact value followed by the air tests of the final assembled aircraft. The statistical results indicate a 52.88% and 34.32% reduction in time delays and total cost, respectively.

Producción Científica

Imran Shafi mail , Muhammad Fawad Mazhar mail , Anum Fatima mail , Roberto Marcelo Álvarez mail roberto.alvarez@uneatlantico.es, Yini Airet Miró Vera mail yini.miro@uneatlantico.es, Julio César Martínez Espinosa mail ulio.martinez@unini.edu.mx, Imran Ashraf mail ,

Shafi

Systematic Review of Machine Learning applied to the Prediction of Obesity and Overweight

Obesity and overweight has increased in the last year and has become a pandemic disease, the result of sedentary lifestyles and unhealthy diets rich in sugars, refined starches, fats and calories. Machine learning (ML) has proven to be very useful in the scientific community, especially in the health sector. With the aim of providing useful tools to help nutritionists and dieticians, research focused on the development of ML and Deep Learning (DL) algorithms and models is searched in the literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol has been used, a very common technique applied to carry out revisions. In our proposal, 17 articles have been filtered in which ML and DL are applied in the prediction of diseases, in the delineation of treatment strategies, in the improvement of personalized nutrition and more. Despite expecting better results with the use of DL, according to the selected investigations, the traditional methods are still the most used and the yields in both cases fluctuate around positive values, conditioned by the databases (transformed in each case) to a greater extent than by the artificial intelligence paradigm used. Conclusions: An important compilation is provided for the literature in this area. ML models are time-consuming to clean data, but (like DL) they allow automatic modeling of large volumes of data which makes them superior to traditional statistics.

Producción Científica

Antonio Ferreras mail , Sandra Sumalla Cano mail sandra.sumalla@uneatlantico.es, Rosmeri Martínez-Licort mail , Iñaki Elío Pascual mail inaki.elio@uneatlantico.es, Kilian Tutusaus mail kilian.tutusaus@uneatlantico.es, Thomas Prola mail thomas.prola@uneatlantico.es, Juan Luis Vidal Mazón mail juanluis.vidal@uneatlantico.es, Benjamín Sahelices mail , Isabel de la Torre Díez mail ,

Ferreras

open

Integration of Sustainable Criteria in the Development of a Proposal for an Online Postgraduate Program in the Projects Area

Regulatory dispersion and a utilitarian use of sustainability deepen the gap within the teaching–learning process and limit the introduction of sustainable criteria in organizations through projects. The objective of this research consisted in developing a sustainable and holistic educational proposal for an online postgraduate program belonging to the Universidad Europea del Atlántico (UNEATLANTICO) within the field of projects. The proposal was based on the instrumentalization of a model comprised of national and international bibliographic references, resulting in a sustainability guide with significant improvements in relation to the reference standard par excellence: ISO 26000:2010. This guide formed the basis of a sustainability management plan, which was key in the project methodology and during the development of sustainable objectives and descriptors for each of the subjects. Lastly, the entities, attributes, and cardinal relationships were established for the development of a physical model used to facilitate the management of all this information within a SQL database. The rigor when determining the educational program, as well as the subsequent analysis of results as supported by the literature review, presupposes the application of this methodology toward other multidisciplinary programs contributing to the adoption of good sustainability practices within the educational field

Producción Científica

Mónica Gracia Villar mail monica.gracia@uneatlantico.es, Roberto Marcelo Álvarez mail roberto.alvarez@uneatlantico.es, Santiago Brie mail santiago.brie@uneatlantico.es, Yini Airet Miró Vera mail yini.miro@uneatlantico.es, Eduardo García Villena mail eduardo.garcia@uneatlantico.es,

Gracia Villar

open

Conformidade legal no ensino superior em Angola: criação de um instrumento de gestão das obrigações legais

O quadro legal angolano para o subsistema de ensino superior cresceu significativamente desde 2009, um crescimento que tem estado a visar o aumento da transparência e da qualidade dos processos educacionais nas instituições de ensino superior (IES) angolanas. Entretanto, a qualidade do ensino superior em Angola não sofreu melhorias significativas por não se estar a cumprir escrupulosamente com o quadro legal de forma sistemática, o que tem resultado em encerramentos de cursos e instituições do ensino superior. Este artigo tem como objetivo principal desenvolver um instrumento de auto- monitorização da conformidade legal que pode ajudar as IES angolanas a tirarem mais proveito do quadro legal do ensino superior. Por intermédio de um levantamento bibliográfico das leis relevantes ao ensino superior em Angola, a identificação de obrigações legais nestas e o desenvolvimento de uma série de tabelas de verificação de conformidade, este estudo apresenta uma checklist de auto verificação da conformidade entre o funcionamento das instituições do ensino superior e o quadro legal relevante ao ensino superior em Angola. Pela utilização deste instrumento, foi possível dissecar as obrigações legais em requisitos ou critérios. Foi também possível estabelecer três graus de conformidade legal, nomeadamente: total, parcial e nenhuma. Notou-se, de igual forma, a existência de um total de 83 obrigações legais das instituições do ensino superior em Angola, sendo os regulamentos e as normas as fontes do maior número de obrigações. Destes, existem entre cinco a quinze requisitos legais por obrigação, perfazendo um volume enorme de requisitos legais com os quais as IES em Angola devem mostrar conformidade legal. A aplicação da checklist permite a gestão desse leque diverso e numeroso de requisitos específicos legais. São sugeridas várias medidas complementares ao quadro legal que devem ser implementadas em Angola com o intuito de se criar uma cultura de conformidade legal no ensino superior, promovendo-se, deste modo, a sua qualidade.

Produção científica

João Manuel da Costa Canoquena mail joao.canoquena@unic.co.ao, María Elena Castro Rodríguez mail maria.rodriguez@unic.co.ao, Yanisleidy Moreira Cabrera mail yanisleidy.cabrera@unic.co.ao,

da Costa Canoquena

open

Contextual Urdu Lemmatization Using Recurrent Neural Network Models

In the field of natural language processing, machine translation is a colossally developing research area that helps humans communicate more effectively by bridging the linguistic gap. In machine translation, normalization and morphological analyses are the first and perhaps the most important modules for information retrieval (IR). To build a morphological analyzer, or to complete the normalization process, it is important to extract the correct root out of different words. Stemming and lemmatization are techniques commonly used to find the correct root words in a language. However, a few studies on IR systems for the Urdu language have shown that lemmatization is more effective than stemming due to infixes found in Urdu words. This paper presents a lemmatization algorithm based on recurrent neural network models for the Urdu language. However, lemmatization techniques for resource-scarce languages such as Urdu are not very common. The proposed model is trained and tested on two datasets, namely, the Urdu Monolingual Corpus (UMC) and the Universal Dependencies Corpus of Urdu (UDU). The datasets are lemmatized with the help of recurrent neural network models. The Word2Vec model and edit trees are used to generate semantic and syntactic embedding. Bidirectional long short-term memory (BiLSTM), bidirectional gated recurrent unit (BiGRU), bidirectional gated recurrent neural network (BiGRNN), and attention-free encoder–decoder (AFED) models are trained under defined hyperparameters. Experimental results show that the attention-free encoder-decoder model achieves an accuracy, precision, recall, and F-score of 0.96, 0.95, 0.95, and 0.95, respectively, and outperforms existing models

Producción Científica

Rabab Hafeez mail , Muhammad Waqas Anwar mail , Muhammad Hasan Jamal mail , Tayyaba Fatima mail , Julio César Martínez Espinosa mail ulio.martinez@unini.edu.mx, Luis Alonso Dzul López mail luis.dzul@uneatlantico.es, Ernesto Bautista Thompson mail ernesto.bautista@unini.edu.mx, Imran Ashraf mail ,

Hafeez

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