Documentos donde el Tema es "Materias > Biomedicina"

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Número de registros en este nivel: 43.

A

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Mobility and low energy consumption are considered the main requirements for wireless body area sensor networks (WBASN) used in healthcare monitoring systems (HMS). In HMS, battery-powered sensor nodes with limited energy are used to obtain vital statistics about the body. Hence, energy-efficient schemes are desired to maintain long-term and steady connectivity of the sensor nodes. A sheer amount of energy is consumed in activities such as idle listening, excessive transmission and reception of control messages, packet collisions and retransmission of packets, and poor path selection, that may lead to more energy consumption. A combination of adaptive scheduling with an energy-efficient protocol can help select an appropriate path at a suitable time to minimize the control overhead, energy consumption, packet collision, and excessive idle listening. This paper proposes a region-based energy-efficient multipath routing (REMR) approach that divides the entire sensor network into clusters with preferably multiple candidates to represent each cluster. The cluster representatives (CRs) route packets through various clusters. For routing, the energy requirement of each route is considered, and the path with minimum energy requirements is selected. Similarly, end-to-end delay, higher throughput, and packet-delivery ratio are considered for packet routing. metadata Akbar, Shuja; Mehdi, Muhammad Mohsin; Jamal, M. Hasan; Raza, Imran; Hussain, Syed Asad; Breñosa, Jose; Martínez Espinosa, Julio César; Pascual Barrera, Alina Eugenia y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, alina.pascual@unini.edu.mx, SIN ESPECIFICAR (2022) Multipath Routing in Wireless Body Area Sensor Network for Healthcare Monitoring. Healthcare, 10 (11). p. 2297. ISSN 2227-9032

Artículo Materias > Biomedicina
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. metadata Armas Diaz, Yasmany; Machì, Michele; Salinari, Alessia; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Briones Urbano, Mercedes y Cianciosi, Danila mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR (2022) Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet. Mediterranean Journal of Nutrition and Metabolism, 15 (4). pp. 581-592. ISSN 1973798X

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Objective This study aims to develop a lightweight convolutional neural network-based edge federated learning architecture for COVID-19 detection using X-ray images, aiming to minimize computational cost, latency, and bandwidth requirements while preserving patient privacy. Method The proposed method uses an edge federated learning architecture to optimize task allocation and execution. Unlike in traditional edge networks where requests from fixed nodes are handled by nearby edge devices or remote clouds, the proposed model uses an intelligent broker within the federation to assess member edge cloudlets' parameters, such as resources and hop count, to make optimal decisions for task offloading. This approach enhances performance and privacy by placing tasks in closer proximity to the user. DenseNet is used for model training, with a depth of 60 and 357,482 parameters. This resource-aware distributed approach optimizes computing resource utilization within the edge-federated learning architecture. Results The experimental results demonstrate significant improvements in various performance metrics. The proposed method reduces training time by 53.1%, optimizes CPU and memory utilization by 17.5% and 33.6%, and maintains accurate COVID-19 detection capabilities without compromising the F1 score, demonstrating the efficiency and effectiveness of the lightweight convolutional neural network-based edge federated learning architecture. Conclusion Existing studies predominantly concentrate on either privacy and accuracy or load balancing and energy optimization, with limited emphasis on training time. The proposed approach offers a comprehensive performance-centric solution that simultaneously addresses privacy, load balancing, and energy optimization while reducing training time, providing a more holistic and balanced solution for optimal system performance. metadata Alvi, Sohaib Bin Khalid; Nayyer, Muhammad Ziad; Jamal, Muhammad Hasan; Raza, Imran; de la Torre Diez, Isabel; Rodríguez Velasco, Carmen Lilí; Breñosa, Jose y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, carmen.rodriguez@uneatlantico.es, josemanuel.brenosa@uneatlantico.es, SIN ESPECIFICAR (2023) A lightweight deep learning approach for COVID-19 detection using X-ray images with edge federation. DIGITAL HEALTH, 9. ISSN 2055-2076

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Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Mutations allow viruses to continuously evolve by changing their genetic code to adapt to the hosts they infect. It is an adaptive and evolutionary mechanism that helps viruses acquire characteristics favoring their survival and propagation. The COVID-19 pandemic declared by the WHO in March 2020 is caused by the SARS-CoV-2 virus. The non-stop adaptive mutations of this virus and the emergence of several variants over time with characteristics favoring their spread constitute one of the biggest obstacles that researchers face in controlling this pandemic. Understanding the mutation mechanism allows for the adoption of anticipatory measures and the proposal of strategies to control its propagation. In this study, we focus on the mutations of this virus, and we propose the SARSMutOnto ontology to model SARS-CoV-2 mutations reported by Pango researchers. A detailed description is given for each mutation. The genes where the mutations occur and the genomic structure of this virus are also included. The sub-lineages and the recombinant sub-lineages resulting from these mutations are additionally represented while maintaining their hierarchy. We developed a Python-based tool to automatically generate this ontology from various published Pango source files. At the end of this paper, we provide some examples of SPARQL queries that can be used to exploit this ontology. SARSMutOnto might become a ‘wet bench’ machine learning tool for predicting likely future mutations based on previous mutations. metadata Bakkas, Jamal; Hanine, Mohamed; Chekry, Abderrahman; Gounane, Said; de la Torre Díez, Isabel; Lipari, Vivian; Martínez López, Nohora Milena y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, nohora.martinez@uneatlantico.es, SIN ESPECIFICAR (2023) SARSMutOnto: An Ontology for SARS-CoV-2 Lineages and Mutations. Viruses, 15 (2). p. 505. ISSN 1999-4915

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Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés The evolution of the COVID-19 pandemic has been associated with variations in clinical presentation and severity. Similarly, prediction scores may suffer changes in their diagnostic accuracy. The aim of this study was to test the 30-day mortality predictive validity of the 4C and SEIMC scores during the sixth wave of the pandemic and to compare them with those of validation studies. This was a longitudinal retrospective observational study. COVID-19 patients who were admitted to the Emergency Department of a Spanish hospital from December 15, 2021, to January 31, 2022, were selected. A side-by-side comparison with the pivotal validation studies was subsequently performed. The main measures were 30-day mortality and the 4C and SEIMC scores. A total of 27,614 patients were considered in the study, including 22,361 from the 4C, 4,627 from the SEIMC and 626 from our hospital. The 30-day mortality rate was significantly lower than that reported in the validation studies. The AUCs were 0.931 (95% CI: 0.90–0.95) for 4C and 0.903 (95% CI: 086–0.93) for SEIMC, which were significantly greater than those obtained in the first wave. Despite the changes that have occurred during the coronavirus disease 2019 (COVID-19) pandemic, with a reduction in lethality, scorecard systems are currently still useful tools for detecting patients with poor disease risk, with better prognostic capacity. metadata de Santos Castro, Pedro Ángel; del Pozo Vegas, Carlos; Pinilla Arribas, Leyre Teresa; Zalama Sánchez, Daniel; Sanz-García, Ancor; Vásquez del Águila, Tony Giancarlo; González Izquierdo, Pablo; de Santos Sánchez, Sara; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR (2024) Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments. Scientific Reports, 14 (1). ISSN 2045-2322

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Objective The aim was to explore the association of demographic and prehospital parameters with short-term and long-term mortality in acute life-threatening cardiovascular disease by using a hazard model, focusing on elderly individuals, by comparing patients under 75 years versus patients over 75 years of age. Design Prospective, multicentre, observational study. Setting Emergency medical services (EMS) delivery study gathering data from two back-to-back studies between 1 October 2019 and 30 November 2021. Six advanced life support (ALS), 43 basic life support and five hospitals in Spain were considered. Participants Adult patients suffering from acute life-threatening cardiovascular disease attended by the EMS. Primary and secondary outcome measures The primary outcome was in-hospital mortality from any cause within the first to the 365 days following EMS attendance. The main measures included prehospital demographics, biochemical variables, prehospital ALS techniques used and syndromic suspected conditions. Results A total of 1744 patients fulfilled the inclusion criteria. The 365-day cumulative mortality in the elderly amounted to 26.1% (229 cases) versus 11.6% (11.6%) in patients under 75 years old. Elderly patients (≥75 years) presented a twofold risk of mortality compared with patients ≤74 years. Life-threatening interventions (mechanical ventilation, cardioversion and defibrillation) were also related to a twofold increased risk of mortality. Importantly, patients suffering from acute heart failure presented a more than twofold increased risk of mortality. Conclusions This study revealed the prehospital variables associated with the long-term mortality of patients suffering from acute cardiovascular disease. Our results provide important insights for the development of specific codes or scores for cardiovascular diseases to facilitate the risk of mortality characterisation. metadata del Pozo Vegas, Carlos; Zalama-Sánchez, Daniel; Sanz-Garcia, Ancor; López-Izquierdo, Raúl; Sáez-Belloso, Silvia; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR (2023) Prehospital acute life-threatening cardiovascular disease in elderly: an observational, prospective, multicentre, ambulance-based cohort study. BMJ Open, 13 (11). e078815. ISSN 2044-6055

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Artículo Materias > Biomedicina
Materias > Ciencias Sociales
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Aim: The development of predictive models for patients treated by emergency medical services (EMS) is on the rise in the emergency field. However, how these models evolve over time has not been studied. The objective of the present work is to compare the characteristics of patients who present mortality in the short, medium and long term, and to derive and validate a predictive model for each mortality time. Methods: A prospective multicenter study was conducted, which included adult patients with unselected acute illness who were treated by EMS. The primary outcome was noncumulative mortality from all causes by time windows including 30-day mortality, 31- to 180-day mortality, and 181- to 365-day mortality. Prehospital predictors included demographic variables, standard vital signs, prehospital laboratory tests, and comorbidities. Results: A total of 4830 patients were enrolled. The noncumulative mortalities at 30, 180, and 365 days were 10.8%, 6.6%, and 3.5%, respectively. The best predictive value was shown for 30-day mortality (AUC = 0.930; 95% CI: 0.919–0.940), followed by 180-day (AUC = 0.852; 95% CI: 0.832–0.871) and 365-day (AUC = 0.806; 95% CI: 0.778–0.833) mortality. Discussion: Rapid characterization of patients at risk of short-, medium-, or long-term mortality could help EMS to improve the treatment of patients suffering from acute illnesses. metadata Enriquez de Salamanca Gambara, Rodrigo; Sanz-García, Ancor; del Pozo Vegas, Carlos; López-Izquierdo, Raúl; Sánchez Soberón, Irene; Delgado Benito, Juan F.; Martínez Díaz, Raquel; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, raquel.martinez@uneatlantico.es, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR (2024) A Comparison of the Clinical Characteristics of Short-, Mid-, and Long-Term Mortality in Patients Attended by the Emergency Medical Services: An Observational Study. Diagnostics, 14 (12). p. 1292. ISSN 2075-4418

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Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Asthma is a deadly disease that affects the lungs and air supply of the human body. Coronavirus and its variants also affect the airways of the lungs. Asthma patients approach hospitals mostly in a critical condition and require emergency treatment, which creates a burden on health institutions during pandemics. The similar symptoms of asthma and coronavirus create confusion for health workers during patient handling and treatment of disease. The unavailability of patient history to physicians causes complications in proper diagnostics and treatments. Many asthma patient deaths have been reported especially during pandemics, which necessitates an efficient framework for asthma patients. In this article, we have proposed a blockchain consortium healthcare framework for asthma patients. The proposed framework helps in managing asthma healthcare units, coronavirus patient records and vaccination centers, insurance companies, and government agencies, which are connected through the secure blockchain network. The proposed framework increases data security and scalability as it stores encrypted patient data on the Interplanetary File System (IPFS) and keeps data hash values on the blockchain. The patient data are traceable and accessible to physicians and stakeholders, which helps in accurate diagnostics, timely treatment, and the management of patients. The smart contract ensures the execution of all business rules. The patient profile generation mechanism is also discussed. The experiment results revealed that the proposed framework has better transaction throughput, query delay, and security than existing solutions metadata Farooq, Muhammad Shoaib; Suhail, Maryam; Qureshi, Junaid Nasir; Rustam, Furqan; de la Torre Díez, Isabel; Vidal Mazón, Juan Luis; Rodríguez Velasco, Carmen Lilí y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, SIN ESPECIFICAR (2022) Consortium Framework Using Blockchain for Asthma Healthcare in Pandemics. Sensors, 22 (21). p. 8582. ISSN 1424-8220

Artículo Materias > Biomedicina
Materias > Ingeniería
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Cerrado Inglés Obesity and overweight has increased in the last year and has become a pandemic disease, the result of sedentary lifestyles and unhealthy diets rich in sugars, refined starches, fats and calories. Machine learning (ML) has proven to be very useful in the scientific community, especially in the health sector. With the aim of providing useful tools to help nutritionists and dieticians, research focused on the development of ML and Deep Learning (DL) algorithms and models is searched in the literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol has been used, a very common technique applied to carry out revisions. In our proposal, 17 articles have been filtered in which ML and DL are applied in the prediction of diseases, in the delineation of treatment strategies, in the improvement of personalized nutrition and more. Despite expecting better results with the use of DL, according to the selected investigations, the traditional methods are still the most used and the yields in both cases fluctuate around positive values, conditioned by the databases (transformed in each case) to a greater extent than by the artificial intelligence paradigm used. Conclusions: An important compilation is provided for the literature in this area. ML models are time-consuming to clean data, but (like DL) they allow automatic modeling of large volumes of data which makes them superior to traditional statistics. metadata Ferreras, Antonio; Sumalla Cano, Sandra; Martínez-Licort, Rosmeri; Elío Pascual, Iñaki; Tutusaus, Kilian; Prola, Thomas; Vidal Mazón, Juan Luis; Sahelices, Benjamín y de la Torre Díez, Isabel mail SIN ESPECIFICAR, sandra.sumalla@uneatlantico.es, SIN ESPECIFICAR, inaki.elio@uneatlantico.es, kilian.tutusaus@uneatlantico.es, thomas.prola@uneatlantico.es, juanluis.vidal@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Systematic Review of Machine Learning applied to the Prediction of Obesity and Overweight. Journal of Medical Systems, 47 (1). ISSN 1573-689X

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Artículo Materias > Biomedicina
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota. metadata Godos, Justyna; Romano, Giovanni Luca; Laudani, Samuele; Gozzo, Lucia; Guerrera, Ida; Dominguez Azpíroz, Irma; Martínez Díaz, Raquel; Quiles, José L.; Battino, Maurizio; Drago, Filippo; Giampieri, Francesca; Galvano, Fabio y Grosso, Giuseppe mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, raquel.martinez@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action. Nutrients, 16 (15). p. 2471. ISSN 2072-6643

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained particular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for modulating the biological activities of phenolic metabolites in humans. The present review aims to summarize the main findings from clinical trials on the effects of resveratrol interventions on endothelial and vascular outcomes and review potential mechanisms interesting the role of gut microbiota on the metabolism of this molecule and its cardioprotective metabolites. The findings from randomized controlled trials show contrasting results on the effects of resveratrol supplementation and vascular biomarkers without dose-dependent effect. In particular, studies in which resveratrol was integrated using food sources, i.e., red wine, reported significant effects although the resveratrol content was, on average, much lower compared to tablet supplementation, while other studies with often extreme resveratrol supplementation resulted in null findings. The results from experimental studies suggest that resveratrol exerts cardioprotective effects through the modulation of various antioxidant, anti-inflammatory, and anti-hypertensive pathways, and microbiota composition. Recent studies on resveratrol-derived metabolites, such as piceatannol, have demonstrated its effects on biomarkers of vascular health. Moreover, resveratrol itself has been shown to improve the gut microbiota composition toward an anti-inflammatory profile. Considering the contrasting findings from clinical studies, future research exploring the bidirectional link between resveratrol metabolism and gut microbiota as well as the mediating effect of gut microbiota in resveratrol effect on cardiovascular health is warranted. metadata Godos, Justyna; Romano, Giovanni Luca; Gozzo, Lucia; Laudani, Samuele; Paladino, Nadia; Dominguez Azpíroz, Irma; Martínez López, Nohora Milena; Giampieri, Francesca; Quiles, José L.; Battino, Maurizio; Galvano, Fabio; Drago, Filippo y Grosso, Giuseppe mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, nohora.martinez@uneatlantico.es, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota. Frontiers in Pharmacology, 15. ISSN 1663-9812

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Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Telephysiotherapy has emerged as a vital solution for delivering remote healthcare, particularly in response to global challenges such as the COVID-19 pandemic. This study seeks to enhance telephysiotherapy by developing a system capable of accurately classifying physiotherapeutic exercises using PoseNet, a state-of-the-art pose estimation model. A dataset was collected from 49 participants (35 males, 14 females) performing seven distinct exercises, with twelve anatomical landmarks then extracted using the Google MediaPipe library. Each landmark was represented by four features, which were used for classification. The core challenge addressed in this research involves ensuring accurate and real-time exercise classification across diverse body morphologies and exercise types. Several tree-based classifiers, including Random Forest, Extra Tree Classifier, XGBoost, LightGBM, and Hist Gradient Boosting, were employed. Furthermore, two novel ensemble models called RandomLightHist Fusion and StackedXLightRF are proposed to enhance classification accuracy. The RandomLightHist Fusion model achieved superior accuracy of 99.6%, demonstrating the system’s robustness and effectiveness. This innovation offers a practical solution for providing real-time feedback in telephysiotherapy, with potential to improve patient outcomes through accurate monitoring and assessment of exercise performance. metadata Hussain, Shahzad; Siddiqui, Hafeez Ur Rehman; Saleem, Adil Ali; Raza, Muhammad Amjad; Alemany Iturriaga, Josep; Velarde-Sotres, Álvaro; Díez, Isabel De la Torre y Dudley, Sandra mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josep.alemany@uneatlantico.es, alvaro.velarde@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Smart Physiotherapy: Advancing Arm-Based Exercise Classification with PoseNet and Ensemble Models. Sensors, 24 (19). p. 6325. ISSN 1424-8220

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Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Objective Epileptic seizures are neurological events that pose significant risks of physical injuries characterized by sudden, abnormal bursts of electrical activity in the brain, often leading to loss of consciousness and uncontrolled movements. Early seizure detection is essential for timely treatments and better patient outcomes. To address this critical issue, there is a need for an advanced artificial intelligence approach for the early detection of epileptic seizure disorder. Methods This study primarily focuses on designing a novel ensemble approach to perform early detection of epileptic seizure disease with high performance. A novel ensemble approach consisting of a fast, independent component analysis random forest (FIR) and prediction probability is proposed, which uses electroencephalography (EEG) data to investigate the efficacy of the proposed approach for early detection of epileptic seizures. The FIR model extracts independent components and class prediction probability features, creating a new feature set. The proposed model combined integrated component analysis (ICA) with predicting probability to enhance seizure recognition accuracy scores. Extensive experimental evaluations demonstrate that FIR assists machine learning models to obtain superior results compared to original features. Results The research gap is addressed using combined features to improve the performance of epileptic seizure detection compared to a single feature set. In particular, the ensemble model FIR with support vector machine (FIR + SVM) outperforms other methods, achieving an accuracy of 98.4% for epileptic seizure detection. Conclusions The proposed FIR has the potential for early diagnosis of epileptic seizures and can significantly help the medical industry with enhanced detection and timely interventions. metadata Khalid, Madiha; Raza, Ali; Akhtar, Adnan; Rustam, Furqan; Brito Ballester, Julién; Rodríguez Velasco, Carmen Lilí; Díez, Isabel de la Torre y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, julien.brito@uneatlantico.es, carmen.rodriguez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Diagnosing epileptic seizures using combined features from independent components and prediction probability from EEG data. DIGITAL HEALTH, 10. ISSN 2055-2076

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Cerrado Inglés Brain–computer interface (BCI) technology holds promise for individuals with profound motor impairments, offering the potential for communication and control. Motor imagery (MI)-based BCI systems are particularly relevant in this context. Despite their potential, achieving accurate and robust classification of MI tasks using electroencephalography (EEG) data remains a significant challenge. In this paper, we employed the Minimum Redundancy Maximum Relevance (MRMR) algorithm to optimize channel selection. Furthermore, we introduced a hybrid optimization approach that combines the War Strategy Optimization (WSO) and Chimp Optimization Algorithm (ChOA). This hybridization significantly enhances the classification model’s overall performance and adaptability. A two-tier deep learning architecture is proposed for classification, consisting of a Convolutional Neural Network (CNN) and a modified Deep Neural Network (M-DNN). The CNN focuses on capturing temporal correlations within EEG data, while the M-DNN is designed to extract high-level spatial characteristics from selected EEG channels. Integrating optimal channel selection, hybrid optimization, and the two-tier deep learning methodology in our BCI framework presents an enhanced approach for precise and effective BCI control. Our model got 95.06% accuracy with high precision. This advancement has the potential to significantly impact neurorehabilitation and assistive technology applications, facilitating improved communication and control for individuals with motor impairments metadata Kumari, Annu; Edla, Damodar Reddy; Reddy, R. Ravinder; Jannu, Srikanth; Vidyarthi, Ankit; Alkhayyat, Ahmed y Garat de Marin, Mirtha Silvana mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, silvana.marin@uneatlantico.es (2024) EEG-based motor imagery channel selection and classification using hybrid optimization and two-tier deep learning. Journal of Neuroscience Methods, 409. p. 110215. ISSN 01650270

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés Leukemia is a type of blood cell cancer that is in the bone marrow’s blood-forming cells. Two types of Leukemia are acute and chronic; acute enhances fast and chronic growth gradually which are further classified into lymphocytic and myeloid leukemias. This work evaluates a unique deep convolutional neural network (CNN) classifier that improves identification precision by carefully examining concatenated peptide patterns. The study uses leukemia protein expression for experiments supporting two different techniques including independence and applied cross-validation. In addition to CNN, multilayer perceptron (MLP), gated recurrent unit (GRU), and recurrent neural network (RNN) are applied. The experimental results show that the CNN model surpasses competitors with its outstanding predictability in independent and cross-validation testing applied on different features extracted from protein expressions such as amino acid composition (AAC) with a group of AAC (GAAC), tripeptide composition (TPC) with a group of TPC (GTPC), and dipeptide composition (DPC) for calculating its accuracies with their receiver operating characteristic (ROC) curve. In independence testing, a feature expression of AAC and a group of GAAC are applied using MLP and CNN modules, and ROC curves are achieved with overall 100% accuracy for the detection of protein patterns. In cross-validation testing, a feature expression on a group of AAC and GAAC patterns achieved 98.33% accuracy which is the highest for the CNN module. Furthermore, ROC curves show a 0.965% extraordinary result for the GRU module. The findings show that the CNN model is excellent at figuring out leukemia illnesses from protein expressions with higher accuracy. metadata Khawaja, Seher Ansar; Farooq, Muhammad Shoaib; Ishaq, Kashif; Alsubaie, Najah; Karamti, Hanen; Caro Montero, Elizabeth; Silva Alvarado, Eduardo René y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, elizabeth.caro@uneatlantico.es, eduardo.silva@funiber.org, SIN ESPECIFICAR (2024) Prediction of leukemia peptides using convolutional neural network and protein compositions. BMC Cancer, 24 (1). ISSN 1471-2407

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Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Emergency medical services (EMSs) face critical situations that require patient risk classification based on analytical and vital signs. We aimed to establish clustering-derived phenotypes based on prehospital analytical and vital signs that allow risk stratification. This was a prospective, multicenter, EMS-delivered, ambulance-based cohort study considering six advanced life support units, 38 basic life support units, and four tertiary hospitals in Spain. Adults with unselected acute diseases managed by the EMS and evacuated with discharge priority to emergency departments were considered between January 1, 2020, and June 30, 2023. Prehospital point-of-care testing and on-scene vital signs were used for the unsupervised machine learning method (clustering) to determine the phenotypes. Then phenotypes were compared with the primary outcome (cumulative mortality (all-cause) at 2, 7, and 30 days). A total of 7909 patients were included. The median (IQR) age was 64 (51–80) years, 41% were women, and 26% were living in rural areas. Three clusters were identified: alpha 16.2% (1281 patients), beta 28.8% (2279), and gamma 55% (4349). The mortality rates for alpha, beta and gamma at 2 days were 18.6%, 4.1%, and 0.8%, respectively; at 7 days, were 24.7%, 6.2%, and 1.7%; and at 30 days, were 33%, 10.2%, and 3.2%, respectively. Based on standard vital signs and blood test biomarkers in the prehospital scenario, three clusters were identified: alpha (high-risk), beta and gamma (medium- and low-risk, respectively). This permits the EMS system to quickly identify patients who are potentially compromised and to proactively implement the necessary interventions. metadata López-Izquierdo, Raúl; del Pozo Vegas, Carlos; Sanz-García, Ancor; Mayo Íscar, Agustín; Castro Villamor, Miguel A.; Silva Alvarado, Eduardo René; Gracia Villar, Santos; Dzul López, Luis Alonso; Aparicio Obregón, Silvia; Calderón Iglesias, Rubén; Soriano, Joan B. y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, eduardo.silva@funiber.org, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, silvia.aparicio@uneatlantico.es, ruben.calderon@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Clinical phenotypes and short-term outcomes based on prehospital point-of-care testing and on-scene vital signs. npj Digital Medicine, 7 (1). ISSN 2398-6352

Artículo Materias > Biomedicina
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results. metadata Laudani, Samuele; Godos, Justyna; Romano, Giovanni Luca; Gozzo, Lucia; Di Domenico, Federica Martina; Dominguez Azpíroz, Irma; Martínez Díaz, Raquel; Giampieri, Francesca; Quiles, José L.; Battino, Maurizio; Drago, Filippo; Galvano, Fabio y Grosso, Giuseppe mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, raquel.martinez@uneatlantico.es, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? Pharmaceuticals, 17 (2). p. 236. ISSN 1424-8247

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Artículo Materias > Biomedicina Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background: Prehospital emergency medical services (EMS) are the main gateway for trauma patients. Recent advances in point-of-care testing and the development of early warning scores have allowed EMS to improve patient classiﬁcation. We aimed to identify patients presenting with major trauma involving life-saving interventions (LSI) using the modiﬁed Sequential Organ Failure Assessment (mSOFA) score in the prehospital scenario, and to compare these results with those of other trauma scores. Methods: This was a prospective, ambulance-based, multicenter, training-validation study in trauma patients who were treated in a prehospital setting and subsequently transported to a hospital. The study involved six Advanced Life Support units, 38 Basic Life Support units, and four hospitals. The primary outcome was LSI performed at the scene or en route and intensive care unit (ICU) admission and all-cause two-day in-hospital mortality. We collected epidemiological variables, creatinine, lactate, base excess, international normalized ratio, and vital signs. Discriminative power (area under the receiver operating characteristic curve [AUC]), calibration (observed vs predicted outcome agreement), and decision-curve analysis (DCA, clinical utility) were used to assess the reliability of the mSOFA in comparison to other scores. Results: Between January 1, 2020–April 30, 2022, a total of 763 patients were selected. The mSOFA score’s AUC was 0.927 (95% conﬁdence interval [CI] 0.898–0.957) for LSI, 0.845 (95% CI 0.808–0.882) for ICU admission, and 0.979 (95% CI 0.966–0.991) for two-day mortality. Conclusion: The mSOFA score outperformed the other scores, allowing a quick identiﬁcation of high-risk patients. The routine implementation in EMS of mSOFA could provide critical support in the decision-making process in time-dependent trauma injuries. metadata Martin-Rodriguez, Francisco; Sanz-Garcia, Ancor; Benito Justel, Ana; Morales Sánchez, Almudena; Mazas Pérez-Oleaga, Cristina; Delgado Noya, Irene; Sánchez Soberón, Irene; Del Pozo Vegas, Carlos; Delgado Benito, Juan F. y López-Izquierdo, Raúl mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irene.delgado@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2013) Prehospital mSOFA Score for Quick Prediction of Life-Saving Interventions and Mortality in Trauma Patients: A Prospective, Multicenter, Ambulance-based, Cohort Study. Western Journal of Emergency Medicine. ISSN 1936-900X

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background: Nowadays, there is no gold standard score for prehospital sepsis and sepsis-related mortality identification. The aim of the present study was to analyze the performance of qSOFA, NEWS2 and mSOFA as sepsis predictors in patients with infection-suspected in prehospital care. The second objective is to study the predictive ability of the aforementioned scores in septic-shock and in-hospital mortality. Methods: Prospective, ambulance-based, and multicenter cohort study, developed by the emergency medical services, among patients (n = 535) with suspected infection transferred by ambulance with high-priority to the emergency department (ED). The study enrolled 40 ambulances and 4 ED in Spain between 1 January 2020, and 30 September 2021. All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. For the evaluation of the scores, the discriminative power, calibration curve and decision curve analysis (DCA) were used. Results: The mSOFA outperformed the other two scores for mortality, presenting the following AUCs: 0.877 (95%CI 0.841–0.913), 0.761 (95%CI 0.706–0.816), 0.731 (95%CI 0.674–0.788), for mSOFA, NEWS, and qSOFA, respectively. No differences were found for sepsis nor septic shock, but mSOFA’s AUCs was higher than the one of the other two scores. The calibration curve and DCA presented similar results. Conclusion: The use of mSOFA could provide and extra insight regarding the short-term mortality and sepsis diagnostic, backing its recommendation in the prehospital scenario. metadata Melero-Guijarro, Laura; Sanz-García, Ancor; Martín-Rodríguez, Francisco; Lipari, Vivian; Mazas Pérez-Oleaga, Cristina; Carvajal-Altamiranda, Stefanía; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma; Castro Villamor, Miguel A.; Sánchez Soberón, Irene y López-Izquierdo, Raúl mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, cristina.mazas@uneatlantico.es, stefania.carvajal@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study. Frontiers in Medicine, 10. ISSN 2296-858X

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Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Cerrado Inglés Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate cancer immunosurveillance, reducing the migration of immunosuppressive regulatory T cells towards the tumor bulk. Autophagy stimulation via reduction of lysine acetylation, increased sensitivity to chemo- and immunotherapy, along with a reduction of insulin-like growth factor 1 and reactive oxygen species have been described as some of the major effects triggered by caloric restriction. Fasting and caloric restriction have also been shown to beneficially influence gut microbiota composition, modify host metabolism, reduce total cholesterol and triglyceride levels, lower diastolic blood pressure and elevate morning cortisol level, with beneficial modulatory effects on cardiopulmonary fitness, body fat and weight, fatigue and weakness, and general quality of life. Moreover, caloric restriction may reduce the carcinogenic and metastatic potential of cancer stem cells, which are generally considered responsible of tumor formation and relapse. Here, we reviewed in vitro and in vivo studies describing the effects of fasting, caloric restriction and some caloric restriction mimetics on immunosurveillance, gut microbiota, metabolism, and cancer stem cell growth, highlighting the molecular and cellular mechanisms underlying these effects. Additionally, studies on caloric restriction interventions in cancer patients or cancer risk subjects are discussed. Considering the promising effects associated with caloric restriction and caloric restriction mimetics, we think that controlled-randomized large clinical trials are warranted to evaluate the inclusion of these non-pharmacological approaches in clinical practice. metadata Pistollato, Francesca; Forbes-Hernández, Tamara Y.; Calderón Iglesias, Rubén; Ruiz Salces, Roberto; Elexpuru Zabaleta, Maria; Dominguez Azpíroz, Irma; Cianciosi, Danila; Quiles, José L.; Giampieri, Francesca y Battino, Maurizio mail francesca.pistollato@uneatlantico.es, SIN ESPECIFICAR, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, maria.elexpuru@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2021) Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment. Seminars in Cancer Biology. pp. 45-57. ISSN 1044-579X

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés The prevalence of anxiety among university students is increasing, resulting in the negative impact on their academic and social (behavioral and emotional) development. In order for students to have competitive academic performance, the cognitive function should be strengthened by detecting and handling anxiety. Over a period of 6 weeks, this study examined how to detect anxiety and how Mano Shakti Yoga (MSY) helps reduce anxiety. Relying on cardiac signals, this study follows an integrated detection-estimation-reduction framework for anxiety using the Intelligent Internet of Medical Things (IIoMT) and MSY. IIoMT is the integration of Internet of Medical Things (wearable smart belt) and machine learning algorithms (Decision Tree (DT), Random Forest (RF), and AdaBoost (AB)). Sixty-six eligible students were selected as experiencing anxiety detected based on the results of self-rating anxiety scale (SAS) questionnaire and a smart belt. Then, the students were divided randomly into two groups: experimental and control. The experimental group followed an MSY intervention for one hour twice a week, while the control group followed their own daily routine. Machine learning algorithms are used to analyze the data obtained from the smart belt. MSY is an alternative improvement for the immune system that helps reduce anxiety. All the results illustrate that the experimental group reduced anxiety with a significant (p < 0.05) difference in group × time interaction compared to the control group. The intelligent techniques achieved maximum accuracy of 80% on using RF algorithm. Thus, students can practice MSY and concentrate on their objectives by improving their intelligence, attention, and memory. metadata Pal, Rishi; Adhikari, Deepak; Heyat, Md Belal Bin; Guragai, Bishal; Lipari, Vivian; Brito Ballester, Julién; De la Torre Díez, Isabel; Abbas, Zia y Lai, Dakun mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, julien.brito@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2022) A Novel Smart Belt for Anxiety Detection, Classification, and Reduction Using IIoMT on Students’ Cardiac Signal and MSY. Bioengineering, 9 (12). p. 793. ISSN 2306-5354

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Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Diabetes is a persistent health condition led by insufficient use or inappropriate use of insulin in the body. If left undetected, it can lead to further complications involving organ damage such as heart, lungs, and eyes. Timely detection of diabetes helps obtain the right medication, diet, and exercise plan to lead a healthy life. ML approach has been utilized to obtain rapid and reliable diabetes detection, however, existing approaches suffer from the use of limited datasets, lack of generalizability, and lower accuracy. This study proposes a novel feature extraction approach to overcome these limitations by using an ensemble of convolutional neural network (CNN) and long short-term memory (LSTM) models. Multiple datasets are combined to make a larger dataset for experiments and multiple features are utilized for investigating the efficacy of the proposed approach. Features from the extra tree classifier, CNN, and LSTM are also considered for comparison. Experimental results reveal the superb performance of CNN-LSTM-based features with random forest model obtaining a 0.99 accuracy score. This performance is further validated by comparison with existing approaches and k-fold cross-validation which shows the proposed approach provides robust results. metadata Rustam, Furqan; Al-Shamayleh, Ahmad Sami; Shafique, Rahman; Aparicio Obregón, Silvia; Calderón Iglesias, Rubén; Gonzalez, J. Pablo Miramontes y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, silvia.aparicio@uneatlantico.es, ruben.calderon@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Enhanced detection of diabetes mellitus using novel ensemble feature engineering approach and machine learning model. Scientific Reports, 14 (1). ISSN 2045-2322

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Thyroid illness encompasses a range of disorders affecting the thyroid gland, leading to either hyperthyroidism or hypothyroidism, which can significantly impact metabolism and overall health. Hypothyroidism can cause a slowdown in bodily processes, leading to symptoms such as fatigue, weight gain, depression, and cold sensitivity. Hyperthyroidism can lead to increased metabolism, causing symptoms like rapid weight loss, anxiety, irritability, and heart palpitations. Prompt diagnosis and appropriate treatment are crucial in managing thyroid disorders and improving patients’ quality of life. Thyroid illness affects millions worldwide and can significantly impact their quality of life if left untreated. This research aims to propose an effective artificial intelligence-based approach for the early diagnosis of thyroid illness. An open-access thyroid disease dataset based on 3,772 male and female patient observations is used for this research experiment. This study uses the nominal continuous synthetic minority oversampling technique (SMOTE-NC) for data balancing and a fine-tuned light gradient booster machine (LGBM) technique to diagnose thyroid illness and handle class imbalance problems. The proposed SNL (SMOTE-NC-LGBM) approach outperformed the state-of-the-art approach with high-accuracy performance scores of 0.96. We have also applied advanced machine learning and deep learning methods for comparison to evaluate performance. Hyperparameter optimizations are also conducted to enhance thyroid diagnosis performance. In addition, we have applied the explainable Artificial Intelligence (XAI) mechanism based on Shapley Additive exPlanations (SHAP) to enhance the transparency and interpretability of the proposed method by analyzing the decision-making processes. The proposed research revolutionizes the diagnosis of thyroid disorders efficiently and helps specialties overcome thyroid disorders early. metadata Raza, Ali; Eid, Fatma; Caro Montero, Elisabeth; Delgado Noya, Irene y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, elizabeth.caro@uneatlantico.es, irene.delgado@uneatlantico.es, SIN ESPECIFICAR (2024) Enhanced interpretable thyroid disease diagnosis by leveraging synthetic oversampling and machine learning models. BMC Medical Informatics and Decision Making, 24 (1). ISSN 1472-6947

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Producción Científica Abierto Inglés White blood cell (WBC) type classification is a task of significant importance for diagnosis using microscopic images of WBC, which develop immunity to fight against infections and foreign substances. WBCs consist of different types, and abnormalities in a type of WBC may potentially represent a disease such as leukemia. Existing studies are limited by low accuracy and overrated performance, often caused by model overfit due to an imbalanced dataset. Additionally, many studies consider a lower number of WBC types, and the accuracy is exaggerated. This study presents a hybrid feature set of selective features and synthetic minority oversampling technique-based resampling to mitigate the influence of the above-mentioned problems. Furthermore, machine learning models are adopted for being less computationally complex, requiring less data for training, and providing robust results. Experiments are performed using both machine- and deep learning models for performance comparison using the original dataset, augmented dataset, and oversampled dataset to analyze the performances of the models. The results suggest that a hybrid feature set of both texture and RGB features from microscopic images, selected using Chi2, produces a high accuracy of 0.97 with random forest. Performance appraisal using k-fold cross-validation and comparison with existing state-of-the-art studies shows that the proposed approach outperforms existing studies regarding the obtained accuracy and computational complexity. metadata Rustam, Furqan; Aslam, Naila; De La Torre Díez, Isabel; Khan, Yaser Daanial; Vidal Mazón, Juan Luis; Rodríguez Velasco, Carmen Lilí y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, SIN ESPECIFICAR (2022) White Blood Cell Classification Using Texture and RGB Features of Oversampled Microscopic Images. Healthcare, 10 (11). p. 2230. ISSN 2227-9032

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Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés In the last decade, artificial intelligence (AI) and AI-mediated technologies have undergone rapid evolution in healthcare and medicine, from apps to computer software able to analyze medical images, robotic surgery and advanced data storage system. The main aim of the present commentary is to briefly describe the evolution of AI and its applications in healthcare, particularly in nutrition and clinical biochemistry. Indeed, AI is revealing itself to be an important tool in clinical nutrition by using telematic means to self-monitor various health metrics, including blood glucose levels, body weight, heart rate, fat percentage, blood pressure, activity tracking and calorie intake trackers. In particular, the application of the most common digital technologies used in the field of nutrition as well as the employment of AI in the management of diabetes and obesity, two of the most common nutrition-related pathologies worldwide, will be presented. metadata Salinari, Alessia; Machì, Michele; Armas Diaz, Yasmany; Cianciosi, Danila; Qi, Zexiu; Yang, Bei; Ferreiro Cotorruelo, Maria Soledad; Gracia Villar, Santos; Dzul López, Luis Alonso; Battino, Maurizio y Giampieri, Francesca mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) The Application of Digital Technologies and Artificial Intelligence in Healthcare: An Overview on Nutrition Assessment. Diseases, 11 (3). p. 97. ISSN 2079-9721

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Artificial intelligence has made substantial progress in medicine. Automated dental imaging interpretation is one of the most prolific areas of research using AI. X-ray and infrared imaging systems have enabled dental clinicians to identify dental diseases since the 1950s. However, the manual process of dental disease assessment is tedious and error-prone when diagnosed by inexperienced dentists. Thus, researchers have employed different advanced computer vision techniques, and machine- and deep-learning models for dental disease diagnoses using X-ray and near-infrared imagery. Despite the notable development of AI in dentistry, certain factors affect the performance of the proposed approaches, including limited data availability, imbalanced classes, and lack of transparency and interpretability. Hence, it is of utmost importance for the research community to formulate suitable approaches, considering the existing challenges and leveraging findings from the existing studies. Based on an extensive literature review, this survey provides a brief overview of X-ray and near-infrared imaging systems. Additionally, a comprehensive insight into challenges faced by researchers in the dental domain has been brought forth in this survey. The article further offers an amalgamative assessment of both performances and methods evaluated on public benchmarks and concludes with ethical considerations and future research avenues. metadata Shafi, Imran; Fatima, Anum; Afzal, Hammad; Díez, Isabel de la Torre; Lipari, Vivian; Breñosa, Jose y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, josemanuel.brenosa@uneatlantico.es, SIN ESPECIFICAR (2023) A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health. Diagnostics, 13 (13). p. 2196. ISSN 2075-4418

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Español Patient care and convenience remain the concern of medical professionals and caregivers alike. An unconscious patient confined to a bed may develop fluid accumulation and pressure sores due to inactivity and deficiency of oxygen flow. Moreover, weight monitoring is crucial for an effective treatment plan, which is difficult to measure for bedridden patients. This paper presents the design and development of a smart and cost-effective independent system for lateral rotation, movement, weight measurement, and transporting immobile patients. Optimal dimensions and practical design specifications are determined by a survey across various hospitals. Subsequently, the proposed hoist-based weighing and turning mechanism is CAD-modeled and simulated. Later, the structural analysis is carried out to select suitable metallurgy for various sub-assemblies to ensure design reliability. After fabrication, optimization, integration, and testing procedures, the base frame is designed to mount a hydraulic motor for the actuator, a DC power source for self-sustenance, and lockable wheels for portability. The installation of a weighing scale and a hydraulic actuator is ensured to lift the patient for weight measuring up to 600 pounds or lateral turning of 80 degrees both ways. The developed system offers simple operating characteristics, allows for keeping patient weight records, and assists nurses in changing patients’ lateral positions both ways, comfortably massage patients’ backs, and transport them from one bed to another. Additionally, being lightweight offers reduced contact with the patient to increase the healthcare staff’s safety in pandemics; it is also height adjustable and portable, allowing for use with multiple-sized beds and easy transportation across the medical facility. The feedback from paramedics is encouraging regarding reducing labor-intensive nursing tasks, alleviating the discomfort of long-term bed-ridden patients, and allowing medical practitioners to suggest better treatment plans metadata Shafi, Imran; Farooq, Muhammad Siddique; De La Torre Díez, Isabel; Breñosa, Jose; Martínez Espinosa, Julio César y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, SIN ESPECIFICAR (2022) Design and Development of Smart Weight Measurement, Lateral Turning and Transfer Bedding for Unconscious Patients in Pandemics. Healthcare, 10 (11). p. 2174. ISSN 2227-9032

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés The diagnosis of early-stage lung cancer is challenging due to its asymptomatic nature, especially given the repeated radiation exposure and high cost of computed tomography(CT). Examining the lung CT images to detect pulmonary nodules, especially the cell lung cancer lesions, is also tedious and prone to errors even by a specialist. This study proposes a cancer diagnostic model based on a deep learning-enabled support vector machine (SVM). The proposed computer-aided design (CAD) model identifies the physiological and pathological changes in the soft tissues of the cross-section in lung cancer lesions. The model is first trained to recognize lung cancer by measuring and comparing the selected profile values in CT images obtained from patients and control patients at their diagnosis. Then, the model is tested and validated using the CT scans of both patients and control patients that are not shown in the training phase. The study investigates 888 annotated CT scans from the publicly available LIDC/IDRI database. The proposed deep learning-assisted SVM-based model yields 94% accuracy for pulmonary nodule detection representing early-stage lung cancer. It is found superior to other existing methods including complex deep learning, simple machine learning, and the hybrid techniques used on lung CT images for nodule detection. Experimental results demonstrate that the proposed approach can greatly assist radiologists in detecting early lung cancer and facilitating the timely management of patients. metadata Shafi, Imran; Din, Sadia; Khan, Asim; Díez, Isabel De La Torre; Pali-Casanova, Ramón; Tutusaus, Kilian y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, ramon.pali@unini.edu.mx, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR (2022) An Effective Method for Lung Cancer Diagnosis from CT Scan Using Deep Learning-Based Support Vector Network. Cancers, 14 (21). p. 5457. ISSN 2072-6694

Artículo Materias > Biomedicina
Materias > Ingeniería
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background and objectives: As microbes are developing resistance to antibiotics, natural, botanical drugs or traditional herbal medicine are presently being studied with an eye of great curiosity and hope. Hence, complementary and alternative treatments for uncomplicated pelvic inflammatory disease (uPID) are explored for their efficacy. Therefore, this study determined the therapeutic efficacy and safety of Sesamum indicum Linn seeds with Rosa damascena Mill Oil in uPID with standard control. Additionally, we analyzed the data with machine learning. Materials and methods: We included 60 participants in a double-blind, double-dummy, randomized standard-controlled study. Participants in the Sesame and Rose oil group (SR group) (n = 30) received 14 days course of black sesame powder (5 gm) mixed with rose oil (10 mL) per vaginum at bedtime once daily plus placebo capsules orally. The standard group (SC), received doxycycline 100 mg twice and metronidazole 400 mg thrice orally plus placebo per vaginum for the same duration. The primary outcome was a clinical cure at post-intervention for visual analogue scale (VAS) for lower abdominal pain (LAP), and McCormack pain scale (McPS) for abdominal-pelvic tenderness. The secondary outcome included white blood cells (WBC) cells in the vaginal wet mount test, safety profile, and health-related quality of life assessed by SF-12. In addition, we used AdaBoost (AB), Naïve Bayes (NB), and Decision Tree (DT) classifiers in this study to analyze the experimental data. Results: The clinical cure for LAP and McPS in the SR vs SC group was 82.85% vs 81.48% and 83.85% vs 81.60% on Day 15 respectively. On Day 15, pus cells less than 10 in the SR vs SC group were 86.6% vs 76.6% respectively. No adverse effects were reported in both groups. The improvement in total SF-12 score on Day 30 for the SR vs SC group was 82.79% vs 80.04% respectively. In addition, our Naive Bayes classifier based on the leave-one-out model achieved the maximum accuracy (68.30%) for the classification of both groups of uPID. Conclusion: We concluded that the SR group is cost-effective, safer, and efficacious for curing uPID. Proposed alternative treatment (test drug) could be a substitute of standard drug used for Female genital tract infections. metadata Sumbul, X.; Sultana, Arshiya; Heyat, Md Belal Bin; Rahman, Khaleequr; Akhtar, Faijan; Parveen, Saba; Briones Urbano, Mercedes; Lipari, Vivian; De la Torre Díez, Isabel; Khan, Azmat Ali y Malik, Abdul mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, mercedes.briones@uneatlantico.es, vivian.lipari@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Efficacy and classification of Sesamum indicum linn seeds with Rosa damascena mill oil in uncomplicated pelvic inflammatory disease using machine learning. Frontiers in Chemistry, 12. ISSN 2296-2646

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés A novel approach is presented in this study for the classification of lower limb disorders, with a specific emphasis on the knee, hip, and ankle. The research employs gait analysis and the extraction of PoseNet features from video data in order to effectively identify and categorize these disorders. The PoseNet algorithm facilitates the extraction of key body joint movements and positions from videos in a non-invasive and user-friendly manner, thereby offering a comprehensive representation of lower limb movements. The features that are extracted are subsequently standardized and employed as inputs for a range of machine learning algorithms, such as Random Forest, Extra Tree Classifier, Multilayer Perceptron, Artificial Neural Networks, and Convolutional Neural Networks. The models undergo training and testing processes using a dataset consisting of 174 real patients and normal individuals collected at the Tehsil Headquarter Hospital Sadiq Abad. The evaluation of their performance is conducted through the utilization of K-fold cross-validation. The findings exhibit a notable level of accuracy and precision in the classification of various lower limb disorders. Notably, the Artificial Neural Networks model achieves the highest accuracy rate of 98.84%. The proposed methodology exhibits potential in enhancing the diagnosis and treatment planning of lower limb disorders. It presents a non-invasive and efficient method of analyzing gait patterns and identifying particular conditions. metadata Siddiqui, Hafeez Ur Rehman; Saleem, Adil Ali; Raza, Muhammad Amjad; Gracia Villar, Santos; Dzul Lopez, Luis; Diez, Isabel de la Torre; Rustam, Furqan y Dudley, Sandra mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, santos.gracia@uneatlantico.es, luis.dzul@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Empowering Lower Limb Disorder Identification through PoseNet and Artificial Intelligence. Diagnostics, 13 (18). p. 2881. ISSN 2075-4418

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background and Aims The 2022-mpox outbreak has spread worldwide in a short time. Integrated knowledge of the epidemiology, clinical characteristics, and transmission of mpox are limited. This systematic review of peer-reviewed articles and gray literature was conducted to shed light on the epidemiology, clinical features, and transmission of 2022-mpox outbreak. Methods We identified 45 peer-reviewed manuscripts for data analysis. The standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement and Cochrane Collaboration were followed for conducting the study. Results The case number of mpox has increased about 100 times worldwide. About 99% of the cases in 2022 outbreak was from non-endemic regions. Men (70%–98% cases) were mostly infected with homosexual and bisexual behavior (30%–60%). The ages of the infected people ranged between 30 and 40 years. The presence of HIV and sexually transmitted infections among 30%–60% of cases were reported. Human-to-human transmission via direct contact and different body fluids were involved in the majority of the cases (90%–100%). Lesions in genitals, perianal, and anogenital areas were more prevalent. Unusually, pharyngitis (15%–40%) and proctitis (20%–40%) were more common during 2022 outbreak than pre-2022 outbreaks. Brincidofovir is approved for the treatment of smallpox by FDA (USA). Two vaccines, including JYNNEOSTM and ACAM2000®, are approved and used for pre- and post-prophylaxis in cases. About 100% of the cases in non-endemic regions were associated with isolates of IIb clade with a divergence of 0.0018–0.0035. Isolates from B.1 lineage were the most predominant followed by B.1.2 and B.1.10. Conclusion This study will add integrated knowledge of the epidemiology, clinical features, and transmission of mpox. metadata Sharif, Nadim; Sharif, Nazmul; Alzahrani, Khalid J.; Halawani, Ibrahim F.; Alzahrani, Fuad M.; Díez, Isabel De la Torre; Lipari, Vivian; López Flores, Miguel Ángel; Parvez, Anowar K. y Dey, Shuvra K. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, miguelangel.lopez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Molecular epidemiology, transmission and clinical features of 2022‐mpox outbreak: A systematic review. Health Science Reports, 6 (10). ISSN 2398-8835

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Lumbar spine stenosis (LSS) is caused by low back pain that exerts pressure on the nerves in the spine. Detecting LSS is a significantly important yet difficult task. It is detected by analyzing the area of the anteroposterior diameter of the patient’s lumbar spine. Currently, the versatility and accuracy of LSS segmentation algorithms are limited. The objective of this research is to use magnetic resonance imaging (MRI) to automatically categorize LSS. This study presents a convolutional neural network (CNN)-based method to detect LSS using MRI images. Radiological grading is performed on a publicly available dataset. Four regions of interest (ROIs) are determined to diagnose LSS with normal, mild, moderate, and severe gradings. The experiments are performed on 1545 axial-view MRI images. Furthermore, two datasets—multi-ROI and single-ROI—are created. For training and testing, an 80:20 ratio of randomly selected labeled datasets is used, with fivefold cross-validation. The results of the proposed model reveal a 97.01% accuracy for multi-ROI and 97.71% accuracy for single-ROI. The proposed computer-aided diagnosis approach can significantly improve diagnostic accuracy in everyday clinical workflows to assist medical experts in decision making. The proposed CNN-based MRI image segmentation approach shows its efficacy on a variety of datasets. Results are compared to existing state-of-the-art studies, indicating the superior performance of the proposed approach. metadata Shahzadi, Turrnum; Ali, Muhammad Usman; Majeed, Fiaz; Sana, Muhammad Usman; Martínez Díaz, Raquel; Samad, Md Abdus y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, raquel.martinez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Nerve Root Compression Analysis to Find Lumbar Spine Stenosis on MRI Using CNN. Diagnostics, 13 (18). p. 2975. ISSN 2075-4418

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Introduction: Rotavirus infection is a major cause of mortality among children under 5 years in Bangladesh. There is lack of integrated studies on rotavirus prevalence and genetic diversity during 1973 to 2023 in Bangladesh. Methods: This meta-analysis was conducted to determine the prevalence, genotypic diversity and seasonal distribution of rotavirus during pre-vaccination period in Bangladesh. This study included published articles on rotavirus A, rotavirus B and rotavirus C. We used Medline, Scopus and Google Scholar for published articles. Selected literatures were published between 1973 to 2023. Results: This study detected 12431 research articles published on rotavirus. Based on the inclusion criteria, 29 of 75 (30.2%) studies were selected. Molecular epidemiological data was taken from 29 articles, prevalence data from 29 articles, and clinical symptoms from 19 articles. The pooled prevalence of rotavirus was 30.1% (95% CI: 22%-45%, p = 0.005). Rotavirus G1 (27.1%, 2228 of 8219) was the most prevalent followed by G2 (21.09%, 1733 of 8219), G4 (11.58%, 952 of 8219), G9 (9.37%, 770 of 8219), G12 (8.48%, 697 of 8219), and G3 (2.79%, 229 of 8219), respectively. Genotype P[8] (40.6%, 2548 of 6274) was the most prevalent followed by P[4] (12.4%, 777 of 6274) and P[6] (6.4%, 400 of 6274), respectively. Rotavirus G1P[8] (19%) was the most frequent followed by G2P [4] (9.4%), G12P[8] (7.2%), and G9P[8], respectively. Rotavirus infection had higher odds of occurrence during December and February (aOR: 2.86, 95% CI: 2.43-3.6, p = 0.001). Discussion: This is the first meta-analysis including all the studies on prevalence, molecular epidemiology, and genetic diversity of rotavirus from 1973 to 2023, pre-vaccination period in Bangladesh. This study will provide overall scenario of rotavirus genetic diversity and seasonality during pre-vaccination period and aids in policy making for rotavirus vaccination program in Bangladesh. This work will add valuable knowledge for vaccination against rotavirus and compare the data after starting vaccination in Bangladesh. metadata Sharif, Nadim; Sharif, Nazmul; Khan, Afsana; Dominguez Azpíroz, Irma; Martínez Díaz, Raquel; Díez, Isabel De la Torre; Parvez, Anowar Khasru y Dey, Shuvra Kanti mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, raquel.martinez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Prevalence and genetic diversity of rotavirus in Bangladesh during pre-vaccination period, 1973-2023: a meta-analysis. Frontiers in Immunology, 14. ISSN 1664-3224

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Introduction: Co-prevalence of long-COVID-19, cardiovascular diseases and diabetes is one of the major health challenges of the pandemic worldwide. Studies on long-COVID-19 and associated health outcomes are absent in Bangladesh. The main aim of this study was to determine the prevalence and impact of long-COVID-19 on preexisting diabetes and cardiovascular diseases (CVD) on health outcomes among patients in Bangladesh. Methods: We collected data from 3,250 participants in Bangladesh, retrospectively. Multivariable logistic regression model was used to determine the odds ratio between independent and dependent variables. Kaplan-Meier survival curve was used to determine the cumulative survival. Results: COVID-19 was detected among 73.4% (2,385 of 3,250) participants. Acute long-COVID-19 was detected among 28.4% (678 of 2,385) and chronic long-COVID-19 among 71.6% (1,707 of 2,385) patients. CVD and diabetes were found among 32%, and 24% patients, respectively. Mortality rate was 18% (585 of 3,250) among the participants. Co-prevalence of CVD, diabetes and COVID-19 was involved in majority of fatality (95%). Fever (97%), dry cough (87%) and loss of taste and smell (85%) were the most prevalent symptoms. Patients with co-prevalence of CVD, diabetes and COVID-19 had higher risk of fatality (OR: 3.65, 95% CI, 2.79–4.24). Co-prevalence of CVD, diabetes and chronic long-COVID-19 were detected among 11.9% patients. Discussion: Risk of hospitalization and fatality reduced significantly among the vaccinated. This is one of the early studies on long-COVID-19 in Bangladesh. metadata Sharif, Nadim; Sharif, Nazmul; Khan, Afsana; Halawani, Ibrahim F.; Alzahrani, Fuad M.; Alzahrani, Khalid J.; Díez, Isabel De la Torre; Ramírez-Vargas, Debora L.; Kuc Castilla, Ángel Gabriel; Parvez, Anowar Khasru y Dey, Shuvra Kanti mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, debora.ramirez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Prevalence and impact of long COVID-19 among patients with diabetes and cardiovascular diseases in Bangladesh. Frontiers in Public Health, 11. ISSN 2296-2565

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Herbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectiveness in alleviating premenstrual symptoms. The published randomized controlled trials (RCTs) were extracted from Google scholar, PubMed, Scopus and PROSPERO databases. The risk of bias in randomized trials was assessed by Cochrane risk-of-bias tool. The main outcome parameters were analysed separately based on the Premenstrual Symptom Screening Tool and PMTS and DRSP scores. Secondary parameters of somatic, psychological, and behavioural subscale symptoms of PSST were also analysed. Data synthesis was performed assuming a random-effects model, and standardized mean difference (SMDs) was analysed using SPSS version 28.0.0 (IBM, Armonk, NY, USA). A total of 754 articles were screened, and 15 RCTs were included (n = 1211 patients). Primary results for participants randomized to an intervention reported reduced PSST (n = 9), PMTS (n = 2), and DSR (n = 4) scores with (SMD = −1.44; 95% CI: −1.72 to −1.17), (SMD = −1.69; 95% CI: −3.80 to 0.42) and (SMD = 2.86; 95% CI: 1.02 to 4.69) verses comparator with substantial heterogeneity. Physical (SMD = −1.61; 95% CI = −2.56 to −0.66), behavioural (SMD = −0.60; 95% CI = −1.55 to0.35) and mood (SMD = 0.57; 95% CI = −0.96 to 2.11) subscale symptom groupings of PSST displayed similar findings. Fifty-three studies (n = 8) were considered at low risk of bias with high quality. Mild adverse events were reported by four RCTs. Based on the existing evidence, herbal medicine and nutritional supplements may be effective and safe for PMS metadata Sultana, Arshiya; Heyat, Md Belal Bin; Rahman, Khaleequr; Kunnavil, Radhika; Fazmiya, Mohamed Joonus Aynul; Akhtar, Faijan; Sumbul, X.; Vidal Mazón, Juan Luis; Rodríguez Velasco, Carmen Lilí y De La Torre Díez, Isabel mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, SIN ESPECIFICAR (2022) A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements. Pharmaceuticals, 15 (11). p. 1371. ISSN 1424-8247

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés This study sought to investigate how different brain regions are affected by Alzheimer’s disease (AD) at various phases of the disease, using independent component analysis (ICA). The study examines six regions in the mild cognitive impairment (MCI) stage, four in the early stage of Alzheimer’s disease (AD), six in the moderate stage, and six in the severe stage. The precuneus, cuneus, middle frontal gyri, calcarine cortex, superior medial frontal gyri, and superior frontal gyri were the areas impacted at all phases. A general linear model (GLM) is used to extract the voxels of the previously mentioned regions. The resting fMRI data for 18 AD patients who had advanced from MCI to stage 3 of the disease were obtained from the ADNI public source database. The subjects include eight women and ten men. The voxel dataset is used to train and test ten machine learning algorithms to categorize the MCI, mild, moderate, and severe stages of Alzheimer’s disease. The accuracy, recall, precision, and F1 score were used as conventional scoring measures to evaluate the classification outcomes. AdaBoost fared better than the other algorithms and obtained a phenomenal accuracy of 98.61%, precision of 99.00%, and recall and F1 scores of 98.00% each. metadata Shahzadi, Samra; Butt, Naveed Anwer; Sana, Muhammad Usman; Elío Pascual, Iñaki; Briones Urbano, Mercedes; Díez, Isabel de la Torre y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, inaki.elio@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Voxel Extraction and Multiclass Classification of Identified Brain Regions across Various Stages of Alzheimer’s Disease Using Machine Learning Approaches. Diagnostics, 13 (18). p. 2871. ISSN 2075-4418

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Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Pregnancy-associated anemia is a significant health issue that poses negative consequences for both the mother and the developing fetus. This study explores the triggering factors of anemia among pregnant females in India, utilizing data from the Demographic and Health Survey 2019–21. Chi-squared and gamma tests were conducted to find out the relationship between anemia and various socioeconomic and sociodemographic elements. Furthermore, ordinal logistic regression and multinomial logistic regression were used to gain deeper insight into the factors that affect anemia among pregnant women in India. According to these findings, anemia affects about 50% of pregnant women in India. Anemia is significantly associated with various factors such as geographical location, level of education, and wealth index. The results of our study indicate that enhancing education and socioeconomic status may serve as viable approaches for mitigating the prevalence of anemia disease developed in pregnant females in India. Employing both Ordinal and Multinominal logistic regression provides a more comprehensive understanding of the risk factors associated with anemia, enabling the development of targeted interventions to prevent and manage this health condition. This paper aims to enhance the efficacy of anemia prevention and management strategies for pregnant women in India by offering an in-depth understanding of the causative factors of anemia. metadata Talin, Iffat Ara; Abid, Mahmudul Hasan; Samad, Md Abdus; Dominguez Azpíroz, Irma; de la Torre Diez, Isabel; Ashraf, Imran y Nahid, Abdullah-Al mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Exploring factors influencing the severity of pregnancy anemia in India: a study using proportional odds model. Scientific Reports, 13 (1). ISSN 2045-2322

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Influence of E-learning training on the acquisition of competences in basketball coaches in Cantabria

The main aim of this study was to analyse the influence of e-learning training on the acquisition of competences in basketball coaches in Cantabria. The current landscape of basketball coach training shows an increasing demand for innovative training models and emerging pedagogies, including e-learning-based methodologies. The study sample consisted of fifty students from these courses, all above 16 years of age (36 males, 14 females). Among them, 16% resided outside the autonomous community of Cantabria, 10% resided more than 50 km from the city of Santander, 36% between 10 and 50 km, 14% less than 10 km, and 24% resided within Santander city. Data were collected through a Google Forms survey distributed by the Cantabrian Basketball Federation to training course students. Participation was voluntary and anonymous. The survey, consisting of 56 questions, was validated by two sports and health doctors and two senior basketball coaches. The collected data were processed and analysed using Microsoft® Excel version 16.74, and the results were expressed in percentages. The analysis revealed that 24.60% of the students trained through the e-learning methodology considered themselves fully qualified as basketball coaches, contrasting with 10.98% of those trained via traditional face-to-face methodology. The results of the study provide insights into important characteristics that can be adjusted and improved within the investigated educational process. Moreover, the study concludes that e-learning training effectively qualifies basketball coaches in Cantabria.

Producción Científica

Josep Alemany Iturriaga mail josep.alemany@uneatlantico.es, Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Javier Jorge mail , Kamil Giglio mail ,

Alemany Iturriaga

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Smart agriculture: utilizing machine learning and deep learning for drought stress identification in crops

Plant stress reduction research has advanced significantly with the use of Artificial Intelligence (AI) techniques, such as machine learning and deep learning. This is a significant step toward sustainable agriculture. Innovative insights into the physiological responses of plants mostly crops to drought stress have been revealed through the use of complex algorithms like gradient boosting, support vector machines (SVM), recurrent neural network (RNN), and long short-term memory (LSTM), combined with a thorough examination of the TYRKC and RBR-E3 domains in stress-associated signaling proteins across a range of crop species. Modern resources were used in this study, including the UniProt protein database for crop physiochemical properties associated with specific signaling domains and the SMART database for signaling protein domains. These insights were then applied to deep learning and machine learning techniques after careful data processing. The rigorous metric evaluations and ablation analysis that typified the study’s approach highlighted the algorithms’ effectiveness and dependability in recognizing and classifying stress events. Notably, the accuracy of SVM was 82%, while gradient boosting and RNN showed 96%, and 94%, respectively and LSTM obtained an astounding 97% accuracy. The study observed these successes but also highlights the ongoing obstacles to AI adoption in agriculture, emphasizing the need for creative thinking and interdisciplinary cooperation. In addition to its scholarly value, the collected data has significant implications for improving resource efficiency, directing precision agricultural methods, and supporting global food security programs. Notably, the gradient boosting and LSTM algorithm outperformed the others with an exceptional accuracy of 96% and 97%, demonstrating their potential for accurate stress categorization. This work highlights the revolutionary potential of AI to completely disrupt the agricultural industry while simultaneously advancing our understanding of plant stress responses.

Producción Científica

Tariq Ali mail , Saif Ur Rehman mail , Shamshair Ali mail , Khalid Mahmood mail , Silvia Aparicio Obregón mail silvia.aparicio@uneatlantico.es, Rubén Calderón Iglesias mail ruben.calderon@uneatlantico.es, Tahir Khurshaid mail , Imran Ashraf mail ,

Ali

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Carotenoids Intake and Cardiovascular Prevention: A Systematic Review

Background: Cardiovascular diseases (CVDs) encompass a variety of conditions that affect the heart and blood vessels. Carotenoids, a group of fat-soluble organic pigments synthesized by plants, fungi, algae, and some bacteria, may have a beneficial effect in reducing cardiovascular disease (CVD) risk. This study aims to examine and synthesize current research on the relationship between carotenoids and CVDs. Methods: A systematic review was conducted using MEDLINE and the Cochrane Library to identify relevant studies on the efficacy of carotenoid supplementation for CVD prevention. Interventional analytical studies (randomized and non-randomized clinical trials) published in English from January 2011 to February 2024 were included. Results: A total of 38 studies were included in the qualitative analysis. Of these, 17 epidemiological studies assessed the relationship between carotenoids and CVDs, 9 examined the effect of carotenoid supplementation, and 12 evaluated dietary interventions. Conclusions: Elevated serum carotenoid levels are associated with reduced CVD risk factors and inflammatory markers. Increasing the consumption of carotenoid-rich foods appears to be more effective than supplementation, though the specific effects of individual carotenoids on CVD risk remain uncertain.

Producción Científica

Sandra Sumalla Cano mail sandra.sumalla@uneatlantico.es, Imanol Eguren García mail imanol.eguren@uneatlantico.es, Álvaro Lasarte García mail , Thomas Prola mail thomas.prola@uneatlantico.es, Raquel Martínez Díaz mail raquel.martinez@uneatlantico.es, Iñaki Elío Pascual mail inaki.elio@uneatlantico.es,

Sumalla Cano

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Roman urdu hate speech detection using hybrid machine learning models and hyperparameter optimization

With the rapid increase of users over social media, cyberbullying, and hate speech problems have arisen over the past years. Automatic hate speech detection (HSD) from text is an emerging research problem in natural language processing (NLP). Researchers developed various approaches to solve the automatic hate speech detection problem using different corpora in various languages, however, research on the Urdu language is rather scarce. This study aims to address the HSD task on Twitter using Roman Urdu text. The contribution of this research is the development of a hybrid model for Roman Urdu HSD, which has not been previously explored. The novel hybrid model integrates deep learning (DL) and transformer models for automatic feature extraction, combined with machine learning algorithms (MLAs) for classification. To further enhance model performance, we employ several hyperparameter optimization (HPO) techniques, including Grid Search (GS), Randomized Search (RS), and Bayesian Optimization with Gaussian Processes (BOGP). Evaluation is carried out on two publicly available benchmarks Roman Urdu corpora comprising HS-RU-20 corpus and RUHSOLD hate speech corpus. Results demonstrate that the Multilingual BERT (MBERT) feature learner, paired with a Support Vector Machine (SVM) classifier and optimized using RS, achieves state-of-the-art performance. On the HS-RU-20 corpus, this model attained an accuracy of 0.93 and an F1 score of 0.95 for the Neutral-Hostile classification task, and an accuracy of 0.89 with an F1 score of 0.88 for the Hate Speech-Offensive task. On the RUHSOLD corpus, the same model achieved an accuracy of 0.95 and an F1 score of 0.94 for the Coarse-grained task, alongside an accuracy of 0.87 and an F1 score of 0.84 for the Fine-grained task. These results demonstrate the effectiveness of our hybrid approach for Roman Urdu hate speech detection.

Producción Científica

Waqar Ashiq mail , Samra Kanwal mail , Adnan Rafique mail , Muhammad Waqas mail , Tahir Khurshaid mail , Elizabeth Caro Montero mail elizabeth.caro@uneatlantico.es, Alicia Bustamante Alonso mail alicia.bustamante@uneatlantico.es, Imran Ashraf mail ,

Ashiq

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Virtual histopathology methods in medical imaging - a systematic review

Virtual histopathology is an emerging technology in medical imaging that utilizes advanced computational methods to analyze tissue images for more precise disease diagnosis. Traditionally, histopathology relies on manual techniques and expertise, often resulting in time-consuming processes and variability in diagnoses. Virtual histopathology offers a more consistent, and automated approach, employing techniques like machine learning, deep learning, and image processing to simulate staining and enhance tissue analysis. This review explores the strengths, limitations, and clinical applications of these methods, highlighting recent advancements in virtual histopathological approaches. In addition, important areas are identified for future research to improve diagnostic accuracy and efficiency in clinical settings.

Producción Científica

Muhammad Talha Imran mail , Imran Shafi mail , Jamil Ahmad mail , Muhammad Fasih Uddin Butt mail , Santos Gracia Villar mail santos.gracia@uneatlantico.es, Eduardo García Villena mail eduardo.garcia@uneatlantico.es, Tahir Khurshaid mail , Imran Ashraf mail ,

Imran

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