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A

Artículo Materias > Ciencias Sociales
Materias > Ingeniería
Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Abierto Inglés Innovation plays a pivotal role in the progress and goodwill of an organization, and its ability to thrive. Consequently, the impact analysis of innovation on the performance of an organization holds great importance. This paper presents a two-stage analytical framework to examine the impact of business innovation on a firm’s performance, especially firms from the manufacturing sector. The prime objective is to identify the factors that have an impact on firm-level innovation, and to examine the impact of firm-level innovation on business performance. The framework and its analysis are based on the latest World Bank enterprise survey, with a sample size of 696 manufacturing firms. The first stage of the proposed framework establishes the analytical results through Bivariate Probit, which indicates that research and development (R&D) has a significantly positive impact on the product, process, marketing, and organizational innovations. It thus highlights the important role of the allocation of lump-sum amounts for R&D activities. The statistical analysis shows that innovation does not depend on the size of the firms. Moreover, the older firms are found to be wiser at conducting R&D than newer firms that are reluctant to take risks. The second stage of the proposed framework separately analyzes the impacts of the product and organizational innovation, and the process and marketing innovation on the firm performance, and finds them to be statistically significant and insignificant, respectively. metadata Aslam, Mahrukh; Shafi, Imran; Ahmad, Jamil; Álvarez, Roberto Marcelo; Miró Vera, Yini Airet; Soriano Flores, Emmanuel y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, roberto.alvarez@uneatlantico.es, yini.miro@uneatlantico.es, emmanuel.soriano@uneatlantico.es, SIN ESPECIFICAR (2022) An Analytical Framework for Innovation Determinants and Their Impact on Business Performance. Sustainability, 15 (1). p. 458. ISSN 2071-1050

B

Artículo Materias > Ciencias Sociales
Materias > Ingeniería
Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Abierto Inglés Financial management is a critical aspect of firms, and entails the strategic planning, direction, and control of financial endeavors. Risk assessment, fraud detection, wealth management, online transactions, customized bond scheme, customer retention, virtual assistant and so on, are a few of the critical areas where Industry 4.0 technologies intervention are highly required for managing firms' finance. It has been identified from the previous studies that they are limited studies that have addressed the significance and application of integrating of Industry 4.0 technologies such as Internet of Things (IoT), cloud computing, big data, robotic process automation (RPA), artificial intelligence (AI), Blockchain, Digital twin, and Metaverse. With the motivation from the above aspects, this study aims to discuss the role of these technologies in the area of financial management of a firm. Based up on the analysis, it has been concluded that these technologies assist to credit risk management based on real-time data; financial data analytics of risk assessment, digital finance, digital auditing, fraud detection, and AI- and IoT- based virtual assistants. This study recommended that digital technologies be deeply integrated into the financial sector to improve service quality and accessibility, as well as the creation of innovative rules that allow for healthy competition among market participants. metadata Bisht, Deepa; Singh, Rajesh; Gehlot, Anita; Akram, Shaik Vaseem; Singh, Aman; Caro Montero, Elisabeth; Priyadarshi, Neeraj y Twala, Bhekisipho mail SIN ESPECIFICAR (2022) Imperative Role of Integrating Digitalization in the Firms Finance: A Technological Perspective. Electronics, 11 (19). p. 3252. ISSN 2079-9292

Artículo Materias > Ciencias Sociales Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Abierto Inglés The primary objectives of this research article were twofold. Firstly, to categorise a total of 294 individuals who aspired to three distinct competency profiles associated with the supervision of international car sales (SPV). Secondly, to prioritise the criteria used for measurement and assess the level of satisfaction attained following the provision of targeted online training for each respective position. Segmentation was performed using the K-Means algorithm on a Likert scale importance questionnaire. Satisfaction indicators were derived by applying fuzzy set methods to the results of a satisfaction questionnaire, also using a Likert scale. The measurement criteria did not show any clear negative perceptions. The overall satisfaction index was 0.7, which was supported by classic statistics and placed in a high category. Additionally, a variable analysis revealed that candidates from the Euro-Asian region exhibited significantly low levels of satisfaction. However, no significant associations were observed between satisfaction levels and gender, income profile, completed training action, or age groups. The researchers rigorously employed a methodology that included assessing the validity and reliability of the instrument. A review of relevant literature also supported the analysis of the results. These findings suggest that the method could be applied to other multidisciplinary programmes to make informed decisions in the field of training. metadata Brito Ballester, Julién; Gracia Villar, Mónica; Soriano Flores, Emmanuel y García Villena, Eduardo mail julien.brito@uneatlantico.es, monica.gracia@uneatlantico.es, emmanuel.soriano@uneatlantico.es, eduardo.garcia@uneatlantico.es (2023) Use of Fuzzy Approach Methodology and Consensus in Creating a Hierarchy of Satisfaction for Measurement Criteria: Application to Online Training Actions Directed at Classification by Key Competency Profiles in Sales Supervision (SPV) within the Automotive. International Journal of Operations and Quantitative Management, 29 (2). pp. 223-251.

C

Artículo Materias > Ciencias Sociales Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Abierto Inglés Angola, as with many countries on the African continent, has great inequalities or asymmetries between its provinces. At the economic, financial, and technological level, there is a great disparity between them, where it is observed that the province of Luanda is the largest financial business center to the detriment of others, such as Moxico, Zaire, and Cabinda. In the latter, despite the advantages of high oil production, from a regional point of view, they remain almost stagnant in time, in a social dysfunction where the population lives on extractivism and artisanal fishing. This article analyzes the most important events in contemporary regional history, the Portuguese occupation that was the Portuguese colonial rule over Angola (1890–1930) and the civil war that was a struggle between Angolans for control of the country (1975–2002), in the consolidation of the asymmetries between provinces. For this work, a theoretical-reflective study was conducted based on the reading of books, articles, and previous investigations on the phenomenon studied. Considering the interpretation and analysis of the theoretical content obtained through the bibliographic research conducted, this theoretical construction approaches the qualitative approach. We conclude that the deep inequalities between regions and within them, between the provinces studied, originated historically in the form of exploitation of the regions and from the consequences of the war. The asymmetries, observed through the variables studied show that the provinces historically explored and considered object regions present a lower growth compared to those that were considered subject regions in which the applied geopolitical strategy, as they are centers of primary production flows, was different. We also observe that, due to the conflicts of the civil war in the less developed regions, the inequalities have deepened, contributing seriously to a higher level of poverty and a lower development of the provinces where these conflicts took place. metadata Catoto Capitango, João Adolfo; Garat de Marin, Mirtha Silvana; Soriano Flores, Emmanuel; Rojo Gutiérrez, Marco Antonio; Gracia Villar, Mónica y Durántez Prados, Frigdiano Álvaro mail SIN ESPECIFICAR, silvana.marin@uneatlantico.es, emmanuel.soriano@uneatlantico.es, marco.rojo@unini.edu.mx, monica.gracia@uneatlantico.es, durantez@uneatlantico.es (2022) Inequalities and Asymmetries in the Development of Angola’s Provinces: The Impact of Colonialism and Civil War. Social Sciences, 11 (8). p. 334. ISSN 2076-0760

Artículo Materias > Ciencias Sociales Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica
Abierto Inglés To improve organisational performance, it is crucial to cultivate an environment and culture that, through shared values, attitudes, behaviours, and sentiments, enables all employees to feel comfortable in performing their work. This represents a recognised gap within the current Cuban business context. Drawing from identified challenges and the introduction of a values-based coaching programme at the state-owned company GEDEME to address this gap, the aim of this study is to evaluate the impact of the values-based coaching programme (CpV) on organisational culture among both tactical and strategic employees within GEDEME. The research adopts a mixed-methods design. On one hand, the non-parametric McNemar test was utilised to assess before-and-after differences, while a case-study approach facilitated the exploration of specific questions, such as identifying the values actually practised beyond those outlined in the formal business plan and understanding the extent and nature of value shifts following the implementation of the coaching programme. The results confirmed the primary hypothesis: the values-based coaching programme at GEDEME had a positive effect on employees' perceptions of organisational culture, resulting in a substantial increase in the number of values both practised and perceived by its members. metadata Caro Montero, Elizabeth; Soriano Flores, Emmanuel; Silva Alvarado, Eduardo René y Garat de Marin, Mirtha Silvana mail elizabeth.caro@uneatlantico.es, emmanuel.soriano@uneatlantico.es, eduardo.silva@funiber.org, silvana.marin@uneatlantico.es (2024) Organizational Culture Assessment Based on a Values-Based Coaching Program for Strategic Level Employees: The Case of GEDEME, Cuba. International Journal of Instructional Cases, 8 (2). pp. 139-163. ISSN 2399-830x

D

Artículo Materias > Ciencias Sociales
Materias > Educación
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Portugués O quadro legal angolano para o subsistema de ensino superior cresceu significativamente desde 2009, um crescimento que tem estado a visar o aumento da transparência e da qualidade dos processos educacionais nas instituições de ensino superior (IES) angolanas. Entretanto, a qualidade do ensino superior em Angola não sofreu melhorias significativas por não se estar a cumprir escrupulosamente com o quadro legal de forma sistemática, o que tem resultado em encerramentos de cursos e instituições do ensino superior. Este artigo tem como objetivo principal desenvolver um instrumento de auto- monitorização da conformidade legal que pode ajudar as IES angolanas a tirarem mais proveito do quadro legal do ensino superior. Por intermédio de um levantamento bibliográfico das leis relevantes ao ensino superior em Angola, a identificação de obrigações legais nestas e o desenvolvimento de uma série de tabelas de verificação de conformidade, este estudo apresenta uma checklist de auto verificação da conformidade entre o funcionamento das instituições do ensino superior e o quadro legal relevante ao ensino superior em Angola. Pela utilização deste instrumento, foi possível dissecar as obrigações legais em requisitos ou critérios. Foi também possível estabelecer três graus de conformidade legal, nomeadamente: total, parcial e nenhuma. Notou-se, de igual forma, a existência de um total de 83 obrigações legais das instituições do ensino superior em Angola, sendo os regulamentos e as normas as fontes do maior número de obrigações. Destes, existem entre cinco a quinze requisitos legais por obrigação, perfazendo um volume enorme de requisitos legais com os quais as IES em Angola devem mostrar conformidade legal. A aplicação da checklist permite a gestão desse leque diverso e numeroso de requisitos específicos legais. São sugeridas várias medidas complementares ao quadro legal que devem ser implementadas em Angola com o intuito de se criar uma cultura de conformidade legal no ensino superior, promovendo-se, deste modo, a sua qualidade. metadata da Costa Canoquena, João Manuel; Castro Rodríguez, María Elena y Moreira Cabrera, Yanisleidy mail joao.canoquena@unic.co.ao, maria.rodriguez@unic.co.ao, yanisleidy.cabrera@unic.co.ao (2023) Conformidade legal no ensino superior em Angola: criação de um instrumento de gestão das obrigações legais. Sapientiae, 8 (2). pp. 203-226. ISSN 2183-5063

E

Artículo Materias > Biomedicina
Materias > Ciencias Sociales
Materias > Ingeniería
Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica
Abierto Inglés Aim: The development of predictive models for patients treated by emergency medical services (EMS) is on the rise in the emergency field. However, how these models evolve over time has not been studied. The objective of the present work is to compare the characteristics of patients who present mortality in the short, medium and long term, and to derive and validate a predictive model for each mortality time. Methods: A prospective multicenter study was conducted, which included adult patients with unselected acute illness who were treated by EMS. The primary outcome was noncumulative mortality from all causes by time windows including 30-day mortality, 31- to 180-day mortality, and 181- to 365-day mortality. Prehospital predictors included demographic variables, standard vital signs, prehospital laboratory tests, and comorbidities. Results: A total of 4830 patients were enrolled. The noncumulative mortalities at 30, 180, and 365 days were 10.8%, 6.6%, and 3.5%, respectively. The best predictive value was shown for 30-day mortality (AUC = 0.930; 95% CI: 0.919–0.940), followed by 180-day (AUC = 0.852; 95% CI: 0.832–0.871) and 365-day (AUC = 0.806; 95% CI: 0.778–0.833) mortality. Discussion: Rapid characterization of patients at risk of short-, medium-, or long-term mortality could help EMS to improve the treatment of patients suffering from acute illnesses. metadata Enriquez de Salamanca Gambara, Rodrigo; Sanz-García, Ancor; del Pozo Vegas, Carlos; López-Izquierdo, Raúl; Sánchez Soberón, Irene; Delgado Benito, Juan F.; Martínez Díaz, Raquel; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma y Martín-Rodríguez, Francisco mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, raquel.martinez@uneatlantico.es, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR (2024) A Comparison of the Clinical Characteristics of Short-, Mid-, and Long-Term Mortality in Patients Attended by the Emergency Medical Services: An Observational Study. Diagnostics, 14 (12). p. 1292. ISSN 2075-4418

Artículo Materias > Ciencias Sociales Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Abierto Inglés In the last two decades, there is an increasingly broad line of studies that warn about the emotional health of journalists and the challenges that it poses for communication professionals to be able to separate work issues from their personal lives. The coverage of COVID-19 exposed many journalists to situations of frustration, discomfort and stress for various reasons: long working hours, not having the appropriate technological material, added to an environment of uncertainty caused by the pandemic. This study aims to examine the possible scope of technostress –in some cases associated to digital divide– in journalists and analyze if they are aware of the uses of care of the self as a way to deal with stressful situations. For this, our research is based on documentary analysis, a survey answered by (50) fifty Argentinean journalists, and twelve (12) in-depth interviews to experienced journalists. Our findings suggest that constant exposure to computers and smartphones during the lockdown together with difficulties to connect to Internet or to have the adequate materials and the lack of coping strategies –as the care of the self– confirms the presence of technostress. Another result that emerges from this research, it should be addressed in future studies, is that some journalists’ reactions about care of the self could respond to the third person effect theory to maintain high self-esteem and not demonstrate vulnerability. metadata Escudero, Carolina; Prola, Thomas; Soriano Flores, Emmanuel y Silva Alvarado, Eduardo René mail SIN ESPECIFICAR, thomas.prola@uneatlantico.es, emmanuel.soriano@uneatlantico.es, eduardo.silva@funiber.org (2023) The Scope of Technostress and Care of The Self on Journalists During the Pandemic. Przestrzeń Społeczna (Social Space), 23 (4). pp. 20-43. ISSN 20841558

G

Artículo Materias > Ciencias Sociales Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Abierto Inglés This article proposes a discussion on the form of coexistence of local Development Agencies in Uruguay, with local governments in the face of the new scenarios marked by the decentralization process, initiated in the country with the Constitutional Reform of 1996 and culminating in February 2009, with the Law of Political Decentralization and Citizen Participation. The discussion applies in particular to the local development agency of the city of Rivera (ADR), located in the northeast of the country. A descriptive, mixed, bibliographic, documentary investigation was carried out with primary data collection to internal and external references to ADR. The results show that the coexistence of both institutions has been difficult, without defining clear roles. Promoting dialogue to define the role of each seems to be the great challenge facing the sustainability of the agency metadata Garat de Marin, Mirtha Silvana; Soriano Flores, Emmanuel; Rodríguez Velasco, Carmen Lilí; Silva Alvarado, Eduardo; Calderón Iglesias, Rubén; Álvarez, Roberto Marcelo y Gracia Villar, Santos mail silvana.marin@uneatlantico.es, emmanuel.soriano@uneatlantico.es, carmen.rodriguez@uneatlantico.es, SIN ESPECIFICAR, ruben.calderon@uneatlantico.es, roberto.alvarez@uneatlantico.es, santos.gracia@uneatlantico.es (2022) Development Agencies and Local Governments—Coexistence within the Same Territory. Social Sciences, 11 (9). p. 398. ISSN 2076-0760

L

Artículo Materias > Ciencias Sociales Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés This article conducted a thematic review on gender-based and sexual violence in the Ecuadorian and Latin American context, aiming to analyze its principal manifestations, impacts, and institutional responses. A qualitative approach was applied, based on the documentary analysis of scientific literature published between 2019 and 2024, reports from international organizations, and current national legislation. The results showed that gender-based violence takes multiple forms, including physical, sexual, psychological, patrimonial, and moral violence, affecting women of all ages in a transversal manner. A high prevalence of domestic and sexual violence was identified, with profound physical and psychological impacts such as post-traumatic stress disorder, depression, and anxiety. Structural risk factors were also recognized, such as patriarchal culture, economic inequality, lack of access to adequate services, and institutional revictimization. Despite legal advancements, significant challenges persist in effectively implementing public policies, comprehensive victim care, and transforming discriminatory cultural patterns. It was concluded that eradicating gender-based violence requires coordinated, sustained, and intersectional action that integrates legal, social, educational, and public health measures aimed at guaranteeing women’s human rights. metadata León Brizuela, Lisandra y Céspedes Tamayo, Leonel mail SIN ESPECIFICAR (2025) Gender-based and sexual violence in Latin America structural factors psychological impacts and challenges of institutional response. Journal of Law and Epistemic Studies, 3 (1). pp. 20-30.

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Liquorice alters adipocyte–breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin–angiotensin signalling

Obesity is recognised to be a risk factor for breast cancer since adipose tissue influences the tumour microenvironment. This study aims to investigate the effect of the secretome of 3T3-L1 adipocytes untreated or treated with liquorice root extract (LRE), containing flavonoids, phenolic acids, and saponins on MCF-7 breast cancer cells. By treating adipocytes with LRE, the secretion of certain pro-tumorigenic factors like IGFBP-6, resistin, and VEGF was reduced. MCF-7 cells exposed to conditioned medium from LRE-treated adipocytes exhibited an increase in reactive oxygen species levels, downregulation of the Nrf2 antioxidant pathway, and increased autophagy. Those conditions reduced cell viability, migration, and colony formation. Additionally, there was downregulation of genes associated with oestrogen signalling and tumour-related processes, including CYP19A1 (aromatase), ERα, Her2, and components of the renin–angiotensin system (RAS). These findings suggest that LRE can modulate the adipocyte secretome to influence breast cancer cell behaviour under obesity-related in vitro conditions.

Producción Científica

Danila Cianciosi mail , Yasmany Armas Diaz mail , Bei Yang mail , Zexiu Qi mail , Ge Chen mail , José L. Quiles mail jose.quiles@uneatlantico.es, Massimiliano Gasparrini mail , Manuela Cassotta mail manucassotta@gmail.com, Rubén Calderón Iglesias mail ruben.calderon@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es, Francesca Giampieri mail francesca.giampieri@uneatlantico.es,

Cianciosi

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An Integrated Machine Learning and Genomic Framework for Precise Detection of Gastric Cancer

This study presents a novel integrative approach for the analysis of high-dimensional gene expression data, leveraging the complementary strengths of unsupervised clustering and supervised classification. Using K-means clustering, the dataset is stratified into three distinct clusters, revealing intrinsic biological patterns and relationships. The resulting cluster assignments are subsequently employed as pseudo-labels to train machine learning models, including support vector machines, random forest, and a stacking ensemble classifier. To validate and enhance the robustness of clustering, complementary methodologies such as hierarchical clustering and DBSCAN are employed, with results visualized through PCA-driven dimensionality reduction. The high predictive accuracy achieved by the classifiers underscores the separability and reliability of the identified clusters. Furthermore, feature importance analysis highlighted key genetic determinants within each cluster, offering actionable insights into potential biomarkers and critical genomic features. This framework bridges the gap between exploratory unsupervised learning and predictive supervised modeling, providing a scalable and interpretable methodology for analyzing complex genomic datasets. Its applicability extends to biomarker discovery, patient stratification, and other precision medicine applications, emphasizing its utility in advancing genomic research and clinical practice.

Producción Científica

Eshmal Iman mail , Sohail Jabbar mail , Shabana Ramzan mail , Ali Raza mail , Farwa Raoof mail , Stefanía Carvajal-Altamiranda mail stefania.carvajal@uneatlantico.es, Vivian Lipari mail vivian.lipari@uneatlantico.es, Imran Ashraf mail ,

Iman

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A novel approach for disease and pests detection in potato production system based on deep learning

Vulnerability of potato crops to diseases and pest infestation can affect its quality and lead to significant yield losses. Timely detection of such diseases can help take effective decisions. For this purpose, a deep learning-based object detection framework is designed in this study to identify and classify major potato diseases and pests under real-world field conditions. A total of 2,688 field images were collected from two research farms in Punjab, Pakistan, across multiple growth stages in various seasonal conditions. Excluding 285 symptoms-free images from the earliest collection led to 2,403 images which were annotated into four biotic-stress classes: blight disease (n = 630), leaf spot disease (n = 370), leafroll virus (viral symptom complex; n = 888), and Colorado potato beetle (larvae/adults; n = 515), indicating class imbalance. Several state-of-the-art models were used including YOLOv8 variants (n/s/m), YOLOv7, YOLOv5, and Faster R-CNN, and the results are discussed in relation to recent potato disease classification studies involving cropped leaf images. Stratified splitting (70% training, 20% validation, 10% testing) was applied to preserve class distribution across all subsets. YOLOv8-medium achieve the best performance with mean average precision (mAP)@0.5 of 98% on the held-out test images. Results for stable 5-fold cross-validation show a mean mAP@0.5 of 97.8%, which offers a balance between accuracy and inference time. Model robustness was evaluated using 5-fold cross-validation and repeated training with different random seeds, showing a low variance of ±0.4% mAP. Results demonstrate promising outcomes under the real-world field conditions, while, broader cross-region and cross-season validation is intended for the future.

Producción Científica

Ahmed Abbas mail , Saif Ur Rehman mail , Khalid Mahmood mail , Santos Gracia Villar mail santos.gracia@uneatlantico.es, Luis Alonso Dzul López mail luis.dzul@uneatlantico.es, Aseel Smerat mail , Imran Ashraf mail ,

Abbas

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Fish consumption and brain structure: a comprehensive systematic review of observational studies

Background Age-related structural changes in the human brain, including cortical atrophy, reductions in grey and white matter volumes, and the accumulation of small vessel–related lesions such as white matter hyperintensities (WMH) and cerebral microbleeds, represent critical biological substrates underlying cognitive decline and dementia. Fish consumption has been associated with slower cognitive decline and reduced risk of dementia, but a comprehensive evaluation of its relation with brain structures is lacking. Aims The aim of this study was to systematically review current scientific literature providing evidence of relation between fish intake and brain structures in human studies. Methods Studies indexed in two major electronic databases have been screened based on a combination of keywords and MeSH terms. Studies were eligible whether they assessed fish consumption in relation to brain structures in the adult populations. Results A total of 24 studies conducted predominantly on older adults met inclusion criteria. Most brain volume measures were obtained via magnetic resonance imaging (MRI) procedures. Higher fish consumption was associated with reduced severity of white matter hyperintensities (a biomarker of cerebral small vessel disease and white matter damage) and cerebral micro-bleed, preservation of certain brain areas volumes (i.e., hippocampus, temporal lobe and periventricle white matter) and cortical thickness of specific areas (i.e., precuneus, parietal, and cingulate grey matter), among others, compared to lower intake. Some analyses found no association and isolated findings suggested possible adverse associations that were not consistently replicated. Studies reporting null findings may underline the possible relevance of the overall diet (i.e., adherence to the Mediterranean diet). Conclusions Inclusion of fish in a healthy and balanced diet is associated with better white matter grades on MRI and slower progression of white matter hyperintensities and reduction of vascular-related lesions of the aging brain, suggesting a potential role in preventing neurocognitive deterioration. Heterogeneity across studies underscores the need for additional studies.

Producción Científica

Justyna Godos mail , Giuseppe Caruso mail , Agnieszka Micek mail , Alberto Dolci mail , Zoltan Ungvari mail , Andrea Lehoczki mail , Lisandra León Brizuela mail , Evelyn Frias-Toral mail , Andrea Di Mauro mail , Mario Siervo mail , Michelino Di Rosa mail , Giuseppe Grosso mail ,

Godos

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Adherence to the Mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adults

Background: Mild Cognitive Impairment (MCI) is viewed as a transitional stage between normal brain aging and dementia and is characterized by subtle cognitive deficits without significant impairment in daily functioning. Growing evidence supports the contribution of neuroinflammation and modifiable lifestyle factors, including diet, in the progression of cognitive decline.Aim: This study aimed to investigate the association between adherence to the Mediterranean diet, neuroinflammatory biomarkers, and MCI status in older adults.Design: Ninety-two participants were enrolled in this cross-sectional study, including 37 subjects with MCI. Dietary intake was assessed using a validated food frequency questionnaire (FFQ) and adherence to the Mediterranean diet explored through the MedDietScore. Plasma levels of TGF-β1 and TNF-α were measured by ELISA. Cognitive status was evaluated using the Mini Mental Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), both adjusted for age and education. Statistical analyses included non-parametric tests, correlation analysis, and logistic regression models.Results: MCI patients showed significantly reduced plasma levels of TGF-β1 and increased TNF-α concentrations compared to other participants. After adjustment for potential confounding factors, greater adherence to the Mediterranean diet was associated with a lower likelihood of MCI in a dose–response manner (highest versus lowest adherence quartile, odds ratio: 0.07, 95% confidence interval: 0.01–0.60). Additional adjustment for inflammatory biomarkers attenuated the associations, suggesting a potential mediating role.Conclusion: Our findings showed that higher adherence to Mediterranean diet is associated with lower likelihood of being MCI. Such a relation might be, at least in part, mediated by inflammatory biomarkers. Overall, these results support the role of dietary modulation in preventive strategies against cognitive decline and progression into MCI.

Producción Científica

Margherita Grasso mail , Francesca L’Episcopo mail , Annamaria Fidilio mail , Marco Antonio Olvera-Moreira mail , Giuseppe Toscano mail , Stefano Muratore mail , Margherita Drago mail , Sabrina Musso mail , Veronica Bentivegna mail , Lucrezia Costanzo mail , Melannie Toral-Noristz mail , Raynier Zambrano-Villacres mail , Lisandra León Brizuela mail , Giuseppe Lanza mail , Raffaele Ferri mail , Filippo Caraci mail ,

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