Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies
Article
Subjects > Biomedicine
Subjects > Nutrition
Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Articles and books
University of La Romana > Research > Scientific Production
Abierto
Inglés
Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer.
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Godos, Justyna and Currenti, Walter and Ferri, Raffaele and Lanza, Giuseppe and Caraci, Filippo and Frias-Toral, Evelyn and Guglielmetti, Monica and Ferraris, Cinzia and Lipari, Vivian and Carvajal Altamiranda, Stefanía and Galvano, Fabio and Castellano, Sabrina and Grosso, Giuseppe
mail
UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, stefania.carvajal@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED
(2025)
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies.
Nutrients, 17 (3).
p. 529.
ISSN 2072-6643
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nutrients-17-00529.pdf Available under License Creative Commons Attribution. Download (703kB) |
Abstract
Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer.
Item Type: | Article |
---|---|
Additional Information: | chronotype; sleep; time-restricted eating; circadian rhythm; metabolic dysregulation; gut microbiota; cancer |
Subjects: | Subjects > Biomedicine Subjects > Nutrition |
Divisions: | Europe University of Atlantic > Research > Scientific Production Fundación Universitaria Internacional de Colombia > Research > Scientific Production Ibero-american International University > Research > Scientific Production Universidad Internacional do Cuanza > Research > Articles and books University of La Romana > Research > Scientific Production |
Date Deposited: | 20 Feb 2025 23:30 |
Last Modified: | 20 Feb 2025 23:30 |
URI: | https://repositorio.unic.co.ao/id/eprint/16759 |
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Background: Scientific research should be carried out to prevent sports injuries. For this purpose, new assessment technologies must be used to analyze and identify the risk factors for injury. The main objective of this systematic review was to compile, synthesize and integrate international research published in different scientific databases on Countermovement Jump (CMJ), Functional Movement Screen (FMS) and Tensiomyography (TMG) tests and technologies for the assessment of injury risk in sport. This way, this review determines the current state of the knowledge about this topic and allows a better understanding of the existing problems, making easier the development of future lines of research. Methodology: A structured search was carried out following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines and the PICOS model until November 30, 2024, in the MEDLINE/PubMed, Web of Science (WOS), ScienceDirect, Cochrane Library, SciELO, EMBASE, SPORTDiscus and Scopus databases. The risk of bias was assessed and the PEDro scale was used to analyze methodological quality. Results: A total of 510 articles were obtained in the initial search. After inclusion and exclusion criteria, the final sample was 40 articles. These studies maintained a high standard of quality. This revealed the effects of the CMJ, FMS and TMG methods for sports injury assessment, indicating the sample population, sport modality, assessment methods, type of research design, study variables, main findings and intervention effects. Conclusions: The CMJ vertical jump allows us to evaluate the power capacity of the lower extremities, both unilaterally and bilaterally, detect neuromuscular asymmetries and evaluate fatigue. Likewise, FMS could be used to assess an athlete's basic movement patterns, mobility and postural stability. Finally, TMG is a non-invasive method to assess the contractile properties of superficial muscles, monitor the effects of training, detect muscle asymmetries, symmetries, provide information on muscle tone and evaluate fatigue. Therefore, they should be considered as assessment tests and technologies to individualize training programs and identify injury risk factors.
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