404 Fichero no Encontrado

No se pudo hallar el fichero: /id/eprint/5633/unic_produccion_cientifica

El fichero indicado no pudo ser encontrado en este servidor. Si ha llegado a esta página siguiendo un enlace del archivo, por favor, contacte con la Uninimx administración. En otro caso, por favor, revise que haya escrito la URL correctamente, o contacte con la persona o sitio que le proporcionó esta URL.

<a class="ep_document_link" href="/11265/1/Food%20Frontiers%20-%202024%20-%20Cassotta%20-%20Human%E2%80%90based%20new%20approach%20methodologies%20to%20accelerate%20advances%20in%20nutrition%20research.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

en

open

Human‐based new approach methodologies to accelerate advances in nutrition research

Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research.

Producción Científica

Manuela Cassotta mail manucassotta@gmail.com, Danila Cianciosi mail , Maria Elexpuru Zabaleta mail maria.elexpuru@uneatlantico.es, Iñaki Elío Pascual mail inaki.elio@uneatlantico.es, Sandra Sumalla Cano mail sandra.sumalla@uneatlantico.es, Francesca Giampieri mail francesca.giampieri@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es,

Cassotta

<a href="/11322/1/journal.pone.0298582.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

en

open

Design and development of patient health tracking, monitoring and big data storage using Internet of Things and real time cloud computing

With the outbreak of the COVID-19 pandemic, social isolation and quarantine have become commonplace across the world. IoT health monitoring solutions eliminate the need for regular doctor visits and interactions among patients and medical personnel. Many patients in wards or intensive care units require continuous monitoring of their health. Continuous patient monitoring is a hectic practice in hospitals with limited staff; in a pandemic situation like COVID-19, it becomes much more difficult practice when hospitals are working at full capacity and there is still a risk of medical workers being infected. In this study, we propose an Internet of Things (IoT)-based patient health monitoring system that collects real-time data on important health indicators such as pulse rate, blood oxygen saturation, and body temperature but can be expanded to include more parameters. Our system is comprised of a hardware component that collects and transmits data from sensors to a cloud-based storage system, where it can be accessed and analyzed by healthcare specialists. The ESP-32 microcontroller interfaces with the multiple sensors and wirelessly transmits the collected data to the cloud storage system. A pulse oximeter is utilized in our system to measure blood oxygen saturation and body temperature, as well as a heart rate monitor to measure pulse rate. A web-based interface is also implemented, allowing healthcare practitioners to access and visualize the collected data in real-time, making remote patient monitoring easier. Overall, our IoT-based patient health monitoring system represents a significant advancement in remote patient monitoring, allowing healthcare practitioners to access real-time data on important health metrics and detect potential health issues before they escalate.

Producción Científica

Md. Milon Islam mail , Imran Shafi mail , Sadia Din mail , Siddique Farooq mail , Isabel de la Torre Díez mail , Jose Breñosa mail josemanuel.brenosa@uneatlantico.es, Julio César Martínez Espinosa mail ulio.martinez@unini.edu.mx, Imran Ashraf mail ,

Islam

<a class="ep_document_link" href="/10845/1/pharmaceuticals-17-00236.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

en

open

Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?

Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results.

Producción Científica

Samuele Laudani mail , Justyna Godos mail , Giovanni Luca Romano mail , Lucia Gozzo mail , Federica Martina Di Domenico mail , Irma Dominguez Azpíroz mail irma.dominguez@unini.edu.mx, Raquel Martínez Díaz mail raquel.martinez@uneatlantico.es, Francesca Giampieri mail francesca.giampieri@uneatlantico.es, José L. Quiles mail jose.quiles@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es, Filippo Drago mail , Fabio Galvano mail , Giuseppe Grosso mail ,

Laudani

<a class="ep_document_link" href="/11065/1/Deep_Learning_Approaches_for_Image_Captioning_Opportunities_Challenges_and_Future_Potential.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

en

open

Deep Learning Approaches for Image Captioning: Opportunities, Challenges and Future Potential

Generative intelligence relies heavily on the integration of vision and language. Much of the research has focused on image captioning, which involves describing images with meaningful sentences. Typically, when generating sentences that describe the visual content, a language model and a vision encoder are commonly employed. Because of the incorporation of object areas, properties, multi-modal connections, attentive techniques, and early fusion approaches like bidirectional encoder representations from transformers (BERT), these components have experienced substantial advancements over the years. This research offers a reference to the body of literature, identifies emerging trends in an area that blends computer vision as well as natural language processing in order to maximize their complementary effects, and identifies the most significant technological improvements in architectures employed for image captioning. It also discusses various problem variants and open challenges. This comparison allows for an objective assessment of different techniques, architectures, and training strategies by identifying the most significant technical innovations, and offers valuable insights into the current landscape of image captioning research.

Producción Científica

Azhar Jamil mail , Saif Ur Rehman mail , Khalid Mahmood mail , Mónica Gracia Villar mail monica.gracia@uneatlantico.es, Thomas Prola mail thomas.prola@uneatlantico.es, Isabel De La Torre Diez mail , Md Abdus Samad mail , Imran Ashraf mail ,

Jamil

<a href="/11174/1/Detecting_Pragmatic_Ambiguity_in_Requirement_Specification_Using_Novel_Concept_Maximum_Matching_Approach_Based_on_Graph_Network.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

en

open

Detecting Pragmatic Ambiguity in Requirement Specification Using Novel Concept Maximum Matching Approach Based on Graph Network

Requirements specifications written in natural language enable us to understand a program’s intended functionality, which we can then translate into operational software. At varying stages of requirement specification, multiple ambiguities emerge. Ambiguities may appear at several levels including the syntactic, semantic, domain, lexical, and pragmatic levels. The primary objective of this study is to identify requirements’ pragmatic ambiguity. Pragmatic ambiguity occurs when the same set of circumstances can be interpreted in multiple ways. It requires consideration of the context statement of the requirements. Prior research has developed methods for obtaining concepts based on individual nodes, so there is room for improvement in the requirements interpretation procedure. This research aims to develop a more effective model for identifying pragmatic ambiguity in requirement definition. To better interpret requirements, we introduced the Concept Maximum Matching (CMM) technique, which extracts concepts based on edges. The CMM technique significantly improves precision because it permits a more accurate interpretation of requirements based on the relative weight of their edges. Obtaining an F-measure score of 0.754 as opposed to 0.563 in existing models, the evaluation results demonstrate that CMM is a substantial improvement over the previous method.

Producción Científica

Khadija Aslam mail , Faiza Iqbal mail , Ayesha Altaf mail , Naveed Hussain mail , Mónica Gracia Villar mail monica.gracia@uneatlantico.es, Emmanuel Soriano Flores mail emmanuel.soriano@uneatlantico.es, Isabel De La Torre Diez mail , Imran Ashraf mail ,

Aslam