Uninimx: Sin condiciones. Resultados ordenados -Depositado. 2024-03-28T12:36:24ZEPrintshttp://repositorio.unic.co.ao/images/sitelogo.pnghttp://repositorio.unic.co.ao/2024-03-14T23:30:21Z2024-03-14T23:30:22Zhttps://repositorio.unic.co.ao/id/eprint/11265Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/112652024-03-14T23:30:21ZHuman‐based new approach methodologies to accelerate advances in nutrition researchMuch of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research.Manuela Cassottamanucassotta@gmail.comDanila CianciosiMaria Elexpuru Zabaletamaria.elexpuru@uneatlantico.esIñaki Elío Pascualinaki.elio@uneatlantico.esSandra Sumalla Canosandra.sumalla@uneatlantico.esFrancesca Giampierifrancesca.giampieri@uneatlantico.esMaurizio Battinomaurizio.battino@uneatlantico.es2024-03-01T13:15:57Z2024-03-01T13:15:58Zhttps://repositorio.unic.co.ao/id/eprint/10840Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/108402024-03-01T13:15:57ZMediterranean Diet and Sleep Features: A Systematic Review of Current EvidenceThe prevalence of sleep disorders, characterized by issues with quality, timing, and sleep duration is increasing globally. Among modifiable risk factors, diet quality has been suggested to influence sleep features. The Mediterranean diet is considered a landmark dietary pattern in terms of quality and effects on human health. However, dietary habits characterized by this cultural heritage should also be considered in the context of overall lifestyle behaviors, including sleep habits. This study aimed to systematically revise the literature relating to adherence to the Mediterranean diet and sleep features in observational studies. The systematic review comprised 23 reports describing the relation between adherence to the Mediterranean diet and different sleep features, including sleep quality, sleep duration, daytime sleepiness, and insomnia symptoms. The majority of the included studies were conducted in the Mediterranean basin and reported a significant association between a higher adherence to the Mediterranean diet and a lower likelihood of having poor sleep quality, inadequate sleep duration, excessive daytime sleepiness or symptoms of insomnia. Interestingly, additional studies conducted outside the Mediterranean basin showed a relationship between the adoption of a Mediterranean-type diet and sleep quality, suggesting that biological mechanisms sustaining such an association may exist. In conclusion, current evidence suggests a relationship between adhering to the Mediterranean diet and overall sleep quality and different sleep parameters. The plausible bidirectional association should be further investigated to understand whether the promotion of a healthy diet could be used as a tool to improve sleep quality.Justyna GodosRaffaele FerriGiuseppe LanzaFilippo CaraciAngel Olider Rojas Vistorteangel.rojas@uneatlantico.esVanessa Yélamos Torresvanessa.yelamos@funiber.orgGiuseppe GrossoSabrina Castellano2024-02-29T20:50:36Z2024-02-29T20:50:39Zhttps://repositorio.unic.co.ao/id/eprint/10845Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/108452024-02-29T20:50:36ZIsoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results.Samuele LaudaniJustyna GodosGiovanni Luca RomanoLucia GozzoFederica Martina Di DomenicoIrma Dominguez Azpírozirma.dominguez@unini.edu.mxRaquel Martínez Díazraquel.martinez@uneatlantico.esFrancesca Giampierifrancesca.giampieri@uneatlantico.esJosé L. Quilesjose.quiles@uneatlantico.esMaurizio Battinomaurizio.battino@uneatlantico.esFilippo DragoFabio GalvanoGiuseppe Grosso2023-12-13T23:30:06Z2023-12-13T23:30:07Zhttps://repositorio.unic.co.ao/id/eprint/239Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/2392023-12-13T23:30:06ZMLS Health and Nutrition ResearchLa revista MLS Health and Nutrition Research nace como una publicación semestral con el objetivo de publicar artículos originales de investigación y de revisión tanto en áreas básicas como aplicadas y metodológicas que supongan una contribución científica al progreso de cualquier ámbito de la salud y nutrición como objetivo principal. Los artículos incluidos en esta revista se publican en español, portugués e inglés. La vocación internacional de esta revista promueve la difusión del conocimiento en sus diferentes áreas.make_name_string expected hash referencemls@devnull.funiber.org2023-10-27T23:30:10Z2023-10-27T23:30:10Zhttps://repositorio.unic.co.ao/id/eprint/9415Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/94152023-10-27T23:30:10ZCLINICALSIM: Clinical simulation practice-based learning in nursingCLINICALSIM is a capability building project targeted to Angola Higher Education Institutions with the aim of improving the practical training of nurses. Nurses are in the focus of health challenges in Angola and they are highly demanded in healthcare, meanwhile their practical competencies are considered as a critical issue. The consortium pursues filling the gap in practical skills (decision-making, interpersonal skills, human nutrition) and promoting HEIs social commitment. We will take advantage of simulation suites and multimedia digital tools to deploy experiential learnings and to promote a Community Service/Service-Learning into the universities.
The experiential learning will take place in three different scenarios: simulation suites, digital multimedia and real patients. A reflective practice methodology with a debriefing process will be followed.
In the context of Service-Learning, we also introduce the social aim of CLINICALSIM and we appoint special considerations to individuals with socio-economic obstacles and health problems and the promotion of better nutrition habits.
CLINICALSIM es un proyecto de desarrollo de capacidades dirigido a las Instituciones de Educación Superior (IES) de Angola con el objetivo de mejorar la formación práctica de los profesionales de la enfermería. Este colectivo se encuentra en el centro de los retos sanitarios en Angola y es muy solicitado en la asistencia sanitaria, mientras que sus competencias prácticas se consideran una cuestión crítica. El consorcio pretende llenar el vacío existente en las habilidades prácticas (toma de decisiones, habilidades interpersonales, nutrición humana) y promover el compromiso social de las IES.
Se aprovecharán las suites de simulación y las herramientas digitales multimedia para desplegar aprendizajes experienciales y promover un Servicio Comunitario/Aprendizaje-Servicio en las universidades.
El aprendizaje experiencial se llevará a cabo en tres escenarios diferentes: salas de simulación, multimedia digital y pacientes reales, siguiendo una metodología de práctica reflexiva con un proceso de debriefing.
En el contexto del Aprendizaje-Servicio, también se introduce el objetivo social de CLINICALSIM y se nombran consideraciones especiales a individuos con obstáculos socioeconómicos y problemas de salud y la promoción de mejores hábitos de nutrición.2023-03-01T23:30:10Z2023-03-01T23:30:11Zhttps://repositorio.unic.co.ao/id/eprint/6096Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/60962023-03-01T23:30:10ZMolecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s DiseaseAlzheimer’s Disease (AD) is the cause of around 60–70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-β formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-κB and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD.Jose M. Romero-MárquezTamara Y. Forbes-HernándezMaría D. Navarro-HortalRosa Quirantes-PinéGiuseppe GrossoFrancesca Giampierifrancesca.giampieri@uneatlantico.esVivian Liparivivian.lipari@uneatlantico.esCristina Sánchez-GonzálezMaurizio Battinomaurizio.battino@uneatlantico.esJosé L. Quilesjose.quiles@uneatlantico.es2023-02-17T23:30:05Z2023-02-17T23:30:07Zhttps://repositorio.unic.co.ao/id/eprint/5929Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/59292023-02-17T23:30:05ZIn Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern SpainThere is growing evidence that Alzheimer’s disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has been tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-β aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans. AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effectsJose M. Romero-MárquezMaría D. Navarro-HortalFrancisco J. OrantesAdelaida Esteban-MuñozCristina Mazas Pérez-Oleagacristina.mazas@uneatlantico.esMaurizio Battinomaurizio.battino@uneatlantico.esCristina Sánchez-GonzálezLorenzo Rivas-GarcíaFrancesca Giampierifrancesca.giampieri@uneatlantico.esJosé L. Quilesjose.quiles@uneatlantico.esTamara Y. Forbes-Hernandeztamara.forbes@unini.edu.mx2023-02-09T23:30:11Z2023-02-09T23:30:11Zhttps://repositorio.unic.co.ao/id/eprint/5793Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/57932023-02-09T23:30:11ZPossible role of nutrition in the prevention of Inflammatory Bowel Disease-related colorectal cancer: a focus on human studiesInflammatory bowel disease (IBD) patients are at substantially higher risk of colorectal cancer (CRC) and IBD-associated CRC accounts for roughly 10-15% of the annual mortality in IBD patients. IBD-related CRC also affects younger patients if compared with sporadic CRC, with a 5-year survival rate of 50%. Regardless of medical therapies, the persistent inflammation state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier disfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. In addition, in the last years, results from broad epidemiological and experimental studies have associated certain foods or nutritional patterns with the risk of colorectal neoplasia. Here we review the possible role of nutrition in the prevention of IBD-related CRC, focusing specifically on human studies. In conclusion it emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, Omega-3 PUFAs, and low amount of animal proteins, processed foods and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC.Manuela Cassottamanucassotta@gmail.comDanila CianciosiRachele De GiuseppeMaria Dolores Navarro-HortalYasmany Armas DiazTamara Yuliett Forbes-HernándezKilian Tutusauskilian.tutusaus@uneatlantico.esAlina Eugenia Pascual Barreraalina.pascual@unini.edu.mxGiuseppe GrossoJianbo XiaoMaurizio Battinomaurizio.battino@uneatlantico.esFrancesca Giampierifrancesca.giampieri@uneatlantico.es2023-01-13T23:30:04Z2023-01-13T23:30:04Zhttps://repositorio.unic.co.ao/id/eprint/5420Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/54202023-01-13T23:30:04ZSystematic Review of Machine Learning applied to the Prediction of Obesity and OverweightObesity and overweight has increased in the last year and has become a pandemic disease, the result of sedentary lifestyles and unhealthy diets rich in sugars, refined starches, fats and calories. Machine learning (ML) has proven to be very useful in the scientific community, especially in the health sector. With the aim of providing useful tools to help nutritionists and dieticians, research focused on the development of ML and Deep Learning (DL) algorithms and models is searched in the literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol has been used, a very common technique applied to carry out revisions. In our proposal, 17 articles have been filtered in which ML and DL are applied in the prediction of diseases, in the delineation of treatment strategies, in the improvement of personalized nutrition and more. Despite expecting better results with the use of DL, according to the selected investigations, the traditional methods are still the most used and the yields in both cases fluctuate around positive values, conditioned by the databases (transformed in each case) to a greater extent than by the artificial intelligence paradigm used. Conclusions: An important compilation is provided for the literature in this area. ML models are time-consuming to clean data, but (like DL) they allow automatic modeling of large volumes of data which makes them superior to traditional statistics.Antonio FerrerasSandra Sumalla Canosandra.sumalla@uneatlantico.esRosmeri Martínez-LicortIñaki Elío Pascualinaki.elio@uneatlantico.esKilian Tutusauskilian.tutusaus@uneatlantico.esThomas Prolathomas.prola@uneatlantico.esJuan Luis Vidal Mazónjuanluis.vidal@uneatlantico.esBenjamín SahelicesIsabel de la Torre Díez2023-01-11T23:30:03Z2023-07-17T23:30:11Zhttps://repositorio.unic.co.ao/id/eprint/5365Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/53652023-01-11T23:30:03ZPrickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean dietCactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases.Yasmany Armas DiazMichele MachìAlessia SalinariCristina Mazas Pérez-Oleagacristina.mazas@uneatlantico.esNohora Milena Martínez Lópeznohora.martinez@uneatlantico.esMercedes Briones Urbanomercedes.briones@uneatlantico.esDanila Cianciosi2022-05-31T18:14:33Z2023-07-10T23:30:13Zhttps://repositorio.unic.co.ao/id/eprint/2117Este registro está en el repositorio con la URL: https://repositorio.unic.co.ao/id/eprint/21172022-05-31T18:14:33ZAdherence to the Mediterranean-Style Eating Pattern and Macular Degeneration: A Systematic Review of Observational StudiesAge-related macular degeneration (AMD) is a serious degenerative disease affecting the eyes, and is the main cause of severe vision loss among people >55 years of age in developed countries. Its onset and progression have been associated with several genetic and lifestyle factors, with diet appearing to play a pivotal role in the latter. In particular, dietary eating patterns rich in plant foods have been shown to lower the risk of developing the disease, and to decrease the odds of progressing to more advanced stages in individuals already burdened with early AMD. We systematically reviewed the literature to analyse the relationship between the adherence to a Mediterranean diet, a mainly plant-based dietary pattern, and the onset/progression of AMD. Eight human observational studies were analysed. Despite some differences, they consistently indicate that higher adherence to a Mediterranean eating pattern lowers the odds of developing AMD and decreases the risk of progression to more advanced stages of the disease, establishing the way for preventative measures emphasizing dietary patterns rich in plant-foodsAnnalisa GastaldelloFrancesca Giampierifrancesca.giampieri@uneatlantico.esJosé L. Quilesjose.quiles@uneatlantico.esMaría D. Navarro-HortalSilvia Aparicio Obregónsilvia.aparicio@uneatlantico.esEduardo García Villenaeduardo.garcia@uneatlantico.esKilian Tutusauskilian.tutusaus@uneatlantico.esRachele De GiuseppeGiuseppe GrossoDanila CianciosiTamara Y. Forbes-HernándezSeyed M. NabaviMaurizio Battinomaurizio.battino@uneatlantico.es