eprintid: 6789 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/00/67/89 datestamp: 2023-04-18 23:30:04 lastmod: 2023-04-18 23:30:07 status_changed: 2023-04-18 23:30:04 type: article metadata_visibility: show creators_name: Melero-Guijarro, Laura creators_name: Sanz-García, Ancor creators_name: Martín-Rodríguez, Francisco creators_name: Lipari, Vivian creators_name: Mazas Pérez-Oleaga, Cristina creators_name: Carvajal-Altamiranda, Stefanía creators_name: Martínez López, Nohora Milena creators_name: Dominguez Azpíroz, Irma creators_name: Castro Villamor, Miguel A. creators_name: Sánchez Soberón, Irene creators_name: López-Izquierdo, Raúl creators_id: creators_id: creators_id: creators_id: vivian.lipari@uneatlantico.es creators_id: cristina.mazas@uneatlantico.es creators_id: stefania.carvajal@uneatlantico.es creators_id: nohora.martinez@uneatlantico.es creators_id: irma.dominguez@unini.edu.mx creators_id: creators_id: creators_id: title: Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica divisions: unincol_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: uninipr_produccion_cientifica divisions: unic_produccion_cientifica full_text_status: public keywords: sepsis, early warning scores, septic shock, point-of-care testing, mSOFA, prehospital abstract: Background: Nowadays, there is no gold standard score for prehospital sepsis and sepsis-related mortality identification. The aim of the present study was to analyze the performance of qSOFA, NEWS2 and mSOFA as sepsis predictors in patients with infection-suspected in prehospital care. The second objective is to study the predictive ability of the aforementioned scores in septic-shock and in-hospital mortality. Methods: Prospective, ambulance-based, and multicenter cohort study, developed by the emergency medical services, among patients (n = 535) with suspected infection transferred by ambulance with high-priority to the emergency department (ED). The study enrolled 40 ambulances and 4 ED in Spain between 1 January 2020, and 30 September 2021. All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. For the evaluation of the scores, the discriminative power, calibration curve and decision curve analysis (DCA) were used. Results: The mSOFA outperformed the other two scores for mortality, presenting the following AUCs: 0.877 (95%CI 0.841–0.913), 0.761 (95%CI 0.706–0.816), 0.731 (95%CI 0.674–0.788), for mSOFA, NEWS, and qSOFA, respectively. No differences were found for sepsis nor septic shock, but mSOFA’s AUCs was higher than the one of the other two scores. The calibration curve and DCA presented similar results. Conclusion: The use of mSOFA could provide and extra insight regarding the short-term mortality and sepsis diagnostic, backing its recommendation in the prehospital scenario. date: 2023 publication: Frontiers in Medicine volume: 10 id_number: doi:10.3389/fmed.2023.1149736 refereed: TRUE issn: 2296-858X official_url: http://doi.org/10.3389/fmed.2023.1149736 access: open language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Abierto Inglés Background: Nowadays, there is no gold standard score for prehospital sepsis and sepsis-related mortality identification. The aim of the present study was to analyze the performance of qSOFA, NEWS2 and mSOFA as sepsis predictors in patients with infection-suspected in prehospital care. The second objective is to study the predictive ability of the aforementioned scores in septic-shock and in-hospital mortality. Methods: Prospective, ambulance-based, and multicenter cohort study, developed by the emergency medical services, among patients (n = 535) with suspected infection transferred by ambulance with high-priority to the emergency department (ED). The study enrolled 40 ambulances and 4 ED in Spain between 1 January 2020, and 30 September 2021. All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. For the evaluation of the scores, the discriminative power, calibration curve and decision curve analysis (DCA) were used. Results: The mSOFA outperformed the other two scores for mortality, presenting the following AUCs: 0.877 (95%CI 0.841–0.913), 0.761 (95%CI 0.706–0.816), 0.731 (95%CI 0.674–0.788), for mSOFA, NEWS, and qSOFA, respectively. No differences were found for sepsis nor septic shock, but mSOFA’s AUCs was higher than the one of the other two scores. The calibration curve and DCA presented similar results. Conclusion: The use of mSOFA could provide and extra insight regarding the short-term mortality and sepsis diagnostic, backing its recommendation in the prehospital scenario. metadata Melero-Guijarro, Laura; Sanz-García, Ancor; Martín-Rodríguez, Francisco; Lipari, Vivian; Mazas Pérez-Oleaga, Cristina; Carvajal-Altamiranda, Stefanía; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma; Castro Villamor, Miguel A.; Sánchez Soberón, Irene y López-Izquierdo, Raúl mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, cristina.mazas@uneatlantico.es, stefania.carvajal@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study. Frontiers in Medicine, 10. ISSN 2296-858X document_url: http://repositorio.unic.co.ao/id/eprint/6789/1/fmed-10-1149736.pdf