eprintid: 4604 rev_number: 11 eprint_status: archive userid: 2 dir: disk0/00/00/46/04 datestamp: 2022-11-16 23:30:07 lastmod: 2023-07-11 23:30:21 status_changed: 2022-11-16 23:30:07 type: article metadata_visibility: show creators_name: Sultana, Arshiya creators_name: Heyat, Md Belal Bin creators_name: Rahman, Khaleequr creators_name: Kunnavil, Radhika creators_name: Fazmiya, Mohamed Joonus Aynul creators_name: Akhtar, Faijan creators_name: Sumbul, X. creators_name: Vidal Mazón, Juan Luis creators_name: Rodríguez Velasco, Carmen Lilí creators_name: De La Torre Díez, Isabel creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: juanluis.vidal@uneatlantico.es creators_id: carmen.rodriguez@uneatlantico.es creators_id: title: A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements ispublished: pub subjects: uneat_bm subjects: uneat_eng divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: unic_produccion_cientifica full_text_status: public keywords: dietary supplements; female health; herbal medicine; PMS; PRISMA; reproductive health; unani medicine; Web of Science; software abstract: Herbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectiveness in alleviating premenstrual symptoms. The published randomized controlled trials (RCTs) were extracted from Google scholar, PubMed, Scopus and PROSPERO databases. The risk of bias in randomized trials was assessed by Cochrane risk-of-bias tool. The main outcome parameters were analysed separately based on the Premenstrual Symptom Screening Tool and PMTS and DRSP scores. Secondary parameters of somatic, psychological, and behavioural subscale symptoms of PSST were also analysed. Data synthesis was performed assuming a random-effects model, and standardized mean difference (SMDs) was analysed using SPSS version 28.0.0 (IBM, Armonk, NY, USA). A total of 754 articles were screened, and 15 RCTs were included (n = 1211 patients). Primary results for participants randomized to an intervention reported reduced PSST (n = 9), PMTS (n = 2), and DSR (n = 4) scores with (SMD = −1.44; 95% CI: −1.72 to −1.17), (SMD = −1.69; 95% CI: −3.80 to 0.42) and (SMD = 2.86; 95% CI: 1.02 to 4.69) verses comparator with substantial heterogeneity. Physical (SMD = −1.61; 95% CI = −2.56 to −0.66), behavioural (SMD = −0.60; 95% CI = −1.55 to0.35) and mood (SMD = 0.57; 95% CI = −0.96 to 2.11) subscale symptom groupings of PSST displayed similar findings. Fifty-three studies (n = 8) were considered at low risk of bias with high quality. Mild adverse events were reported by four RCTs. Based on the existing evidence, herbal medicine and nutritional supplements may be effective and safe for PMS date: 2022-11 date_type: published publication: Pharmaceuticals volume: 15 number: 11 pagerange: 1371 id_number: doi:10.3390/ph15111371 refereed: TRUE issn: 1424-8247 official_url: http://doi.org/10.3390/ph15111371 access: open language: en citation: Artículo Materias > Biomedicina Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Abierto Inglés Herbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectiveness in alleviating premenstrual symptoms. The published randomized controlled trials (RCTs) were extracted from Google scholar, PubMed, Scopus and PROSPERO databases. The risk of bias in randomized trials was assessed by Cochrane risk-of-bias tool. The main outcome parameters were analysed separately based on the Premenstrual Symptom Screening Tool and PMTS and DRSP scores. Secondary parameters of somatic, psychological, and behavioural subscale symptoms of PSST were also analysed. Data synthesis was performed assuming a random-effects model, and standardized mean difference (SMDs) was analysed using SPSS version 28.0.0 (IBM, Armonk, NY, USA). A total of 754 articles were screened, and 15 RCTs were included (n = 1211 patients). Primary results for participants randomized to an intervention reported reduced PSST (n = 9), PMTS (n = 2), and DSR (n = 4) scores with (SMD = −1.44; 95% CI: −1.72 to −1.17), (SMD = −1.69; 95% CI: −3.80 to 0.42) and (SMD = 2.86; 95% CI: 1.02 to 4.69) verses comparator with substantial heterogeneity. Physical (SMD = −1.61; 95% CI = −2.56 to −0.66), behavioural (SMD = −0.60; 95% CI = −1.55 to0.35) and mood (SMD = 0.57; 95% CI = −0.96 to 2.11) subscale symptom groupings of PSST displayed similar findings. Fifty-three studies (n = 8) were considered at low risk of bias with high quality. Mild adverse events were reported by four RCTs. Based on the existing evidence, herbal medicine and nutritional supplements may be effective and safe for PMS metadata Sultana, Arshiya; Heyat, Md Belal Bin; Rahman, Khaleequr; Kunnavil, Radhika; Fazmiya, Mohamed Joonus Aynul; Akhtar, Faijan; Sumbul, X.; Vidal Mazón, Juan Luis; Rodríguez Velasco, Carmen Lilí y De La Torre Díez, Isabel mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, SIN ESPECIFICAR (2022) A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements. Pharmaceuticals, 15 (11). p. 1371. ISSN 1424-8247 document_url: http://repositorio.unic.co.ao/id/eprint/4604/1/pharmaceuticals-15-01371-v2.pdf