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primary topic: Liquorice alters adipocyte–breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin–angiotensin signalling

Liquorice alters adipocyte–breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin–angiotensin signalling
type: AcademicArticle
type: Article
abstract: Obesity is recognised to be a risk factor for breast cancer since adipose tissue influences the tumour microenvironment. This study aims to investigate the effect of the secretome of 3T3-L1 adipocytes untreated or treated with liquorice root extract (LRE), containing flavonoids, phenolic acids, and saponins on MCF-7 breast cancer cells. By treating adipocytes with LRE, the secretion of certain pro-tumorigenic factors like IGFBP-6, resistin, and VEGF was reduced. MCF-7 cells exposed to conditioned medium from LRE-treated adipocytes exhibited an increase in reactive oxygen species levels, downregulation of the Nrf2 antioxidant pathway, and increased autophagy. Those conditions reduced cell viability, migration, and colony formation. Additionally, there was downregulation of genes associated with oestrogen signalling and tumour-related processes, including CYP19A1 (aromatase), ERα, Her2, and components of the renin–angiotensin system (RAS). These findings suggest that LRE can modulate the adipocyte secretome to influence breast cancer cell behaviour under obesity-related in vitro conditions.
date: 2026-05
is part of: International Journal of Food Sciences and Nutrition
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: Biomedicine
subject: Nutrition

International Journal of Food Sciences and Nutrition
type: Collection
issn: 09637486

Rubén Calderón Iglesias
type: Person
given name: Rubén
family name: Calderón Iglesias

Bei Yang
type: Person
given name: Bei
family name: Yang

Zexiu Qi
type: Person
given name: Zexiu
family name: Qi

Danila Cianciosi
type: Person
given name: Danila
family name: Cianciosi

Ge Chen
type: Person
given name: Ge
family name: Chen

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Manuela Cassotta
type: Person
given name: Manuela
family name: Cassotta

Massimiliano Gasparrini
type: Person
given name: Massimiliano
family name: Gasparrini

Yasmany Armas Diaz
type: Person
given name: Yasmany
family name: Armas Diaz

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

José L. Quiles
type: Person
given name: José L.
family name: Quiles

HTML Summary of #28571 Liquorice alters adipocyte–breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin–angiotensin signalling
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primary topic: Liquorice alters adipocyte–breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin–angiotensin signalling

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es