<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations"^^ . "Understanding how dietary compounds affect human health is challenged by their molecular complexity and cell-type–specific effects. Conventional multi-cell type (bulk) analyses obscure cellular heterogeneity, while animal and standard in vitro models often fail to replicate human physiology. Single-cell omics technologies—such as single-cell RNA sequencing, as well as single-cell–resolved proteomic and metabolomic approaches—enable high-resolution investigation of nutrient–cell interactions and reveal mechanisms at a single-cell resolution. When combined with advanced human-derived in vitro systems like organoids and organ-on-chip platforms, they support mechanistic studies in physiologically relevant contexts. This review outlines emerging applications of single-cell omics in nutrition research, emphasizing their potential to uncover cell-specific dietary responses, identify nutrient-sensitive pathways, and capture interindividual variability. It also discusses key challenges—including technical limitations, model selection, and institutional biases—and identifies strategic directions to facilitate broader adoption in the field. Collectively, single-cell omics offer a transformative framework to advance human-centric nutrition research."^^ . "2025-11" . . . "Critical Reviews in Food Science and Nutrition"^^ . . . "10408398" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Francesca"^^ . "Giampieri"^^ . "Francesca Giampieri"^^ . . "Ge"^^ . "Chen"^^ . "Ge Chen"^^ . . "José L."^^ . "Quiles"^^ . "José L. Quiles"^^ . . "Manuela"^^ . "Cassotta"^^ . "Manuela Cassotta"^^ . . "Danila"^^ . "Cianciosi"^^ . "Danila Cianciosi"^^ . . "Luis Alonso"^^ . "Dzul López"^^ . "Luis Alonso Dzul López"^^ . . "Giuseppe"^^ . "Grosso"^^ . "Giuseppe Grosso"^^ . . "Yasmany"^^ . "Armas Diaz"^^ . "Yasmany Armas Diaz"^^ . . "Zexiu"^^ . "Qi"^^ . "Zexiu Qi"^^ . . "Jianbo"^^ . "Xiao"^^ . "Jianbo Xiao"^^ . . "Maurizio"^^ . "Battino"^^ . "Maurizio Battino"^^ . . "Bei"^^ . "Yang"^^ . "Bei Yang"^^ . . "Santos"^^ . "Gracia Villar"^^ . "Santos Gracia Villar"^^ . . . . . "HTML Summary of #17867 \n\nSingle-cell omics for nutrition research: an emerging opportunity for human-centric investigations\n\n" . "text/html" . . . "Nutrition"@en . "Alimentación"@es . .