<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action"^^ . "Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota."^^ . "2024-07" . . . "16" . "15" . . "Nutrients"^^ . . . "20726643" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Fabio"^^ . "Galvano"^^ . "Fabio Galvano"^^ . . "José L."^^ . "Quiles"^^ . "José L. Quiles"^^ . . "Francesca"^^ . "Giampieri"^^ . "Francesca Giampieri"^^ . . "Samuele"^^ . "Laudani"^^ . "Samuele Laudani"^^ . . "Giuseppe"^^ . "Grosso"^^ . "Giuseppe Grosso"^^ . . "Giovanni Luca"^^ . "Romano"^^ . "Giovanni Luca Romano"^^ . . "Filippo"^^ . "Drago"^^ . "Filippo Drago"^^ . . "Raquel"^^ . "Martínez Díaz"^^ . "Raquel Martínez Díaz"^^ . . "Irma"^^ . "Dominguez Azpíroz"^^ . "Irma Dominguez Azpíroz"^^ . . "Justyna"^^ . "Godos"^^ . "Justyna Godos"^^ . . "Ida"^^ . "Guerrera"^^ . "Ida Guerrera"^^ . . "Lucia"^^ . "Gozzo"^^ . "Lucia Gozzo"^^ . . "Maurizio"^^ . "Battino"^^ . "Maurizio Battino"^^ . . . . . . "Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)"^^ . . . "nutrients-16-02471.pdf"^^ . . . "Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Otro)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #14366 \n\nFlavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . . . "Nutrition"@en . "Alimentación"@es . .