@article{unic14366,
          volume = {16},
          number = {15},
           month = {Julio},
           pages = {2471},
           title = {Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action},
            year = {2024},
         journal = {Nutrients},
          author = {Justyna Godos and Giovanni Luca Romano and Samuele Laudani and Lucia Gozzo and Ida Guerrera and Irma Dominguez Azp{\'i}roz and Raquel Mart{\'i}nez D{\'i}az and Jos{\'e} L. Quiles and Maurizio Battino and Filippo Drago and Francesca Giampieri and Fabio Galvano and Giuseppe Grosso},
             url = {http://repositorio.unic.co.ao/id/eprint/14366/},
        abstract = {Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota.},
        keywords = {flavan-3-ols; polyphenols; inflammation; vascular; gut microbiota}
}