eprintid: 10845 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/01/08/45 datestamp: 2024-02-29 20:50:36 lastmod: 2024-02-29 20:50:39 status_changed: 2024-02-29 20:50:36 type: article metadata_visibility: show creators_name: Laudani, Samuele creators_name: Godos, Justyna creators_name: Romano, Giovanni Luca creators_name: Gozzo, Lucia creators_name: Di Domenico, Federica Martina creators_name: Dominguez Azpíroz, Irma creators_name: Martínez Díaz, Raquel creators_name: Giampieri, Francesca creators_name: Quiles, José L. creators_name: Battino, Maurizio creators_name: Drago, Filippo creators_name: Galvano, Fabio creators_name: Grosso, Giuseppe creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: irma.dominguez@unini.edu.mx creators_id: raquel.martinez@uneatlantico.es creators_id: francesca.giampieri@uneatlantico.es creators_id: jose.quiles@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: creators_id: title: Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? ispublished: pub subjects: uneat_bm subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: uninipr_produccion_cientifica divisions: unic_produccion_cientifica divisions: uniromana_produccion_cientifica full_text_status: public keywords: isoflavones; polyphenols; phytoestrogens; equol; vascular; gut microbiota abstract: Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results. date: 2024-02 publication: Pharmaceuticals volume: 17 number: 2 pagerange: 236 id_number: doi:10.3390/ph17020236 refereed: TRUE issn: 1424-8247 official_url: http://doi.org/10.3390/ph17020236 access: open language: en citation: Artículo Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results. metadata Laudani, Samuele; Godos, Justyna; Romano, Giovanni Luca; Gozzo, Lucia; Di Domenico, Federica Martina; Dominguez Azpíroz, Irma; Martínez Díaz, Raquel; Giampieri, Francesca; Quiles, José L.; Battino, Maurizio; Drago, Filippo; Galvano, Fabio y Grosso, Giuseppe mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, raquel.martinez@uneatlantico.es, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? Pharmaceuticals, 17 (2). p. 236. ISSN 1424-8247 document_url: http://repositorio.unic.co.ao/id/eprint/10845/1/pharmaceuticals-17-00236.pdf